Synthesis of SMP-797: a new potent ACAT inhibitor

被引：14

作者：

Ban, H ^{[1
]}

Muraoka, M ^{[1
]}

Ohashi, N ^{[1
]}

机构：

[1] Sumitomo Pharmaceut Co Ltd, Div Res, Kohohana Ku, Osaka 5540022, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 42期

关键词：

cyclization; Friedlander reaction; Suzuki coupling; 4-selective nitration; SMP-797;

D O I：

10.1016/j.tet.2005.08.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8-naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：10081 / 10092

页数：12

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