Droplet organelles?

被引：232

作者：

Courchaine, Edward M. ^{[1
]}

Lu, Alice ^{[1
]}

Neugebauer, Karla M. ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

EMBO JOURNAL | 2016年 / 35卷 / 15期

基金：

美国国家科学基金会;

关键词：

Liquid-liquid phase separation; low-complexity domain; nuclear bodies; RNP granules; RNA-BINDING PROTEINS; PRION-LIKE DOMAINS; INTRINSICALLY DISORDERED PROTEINS; EUKARYOTIC STRESS GRANULES; LOW-COMPLEXITY DOMAINS; CAJAL BODIES; PHASE-TRANSITION; LIQUID DROPLETS; NUCLEAR-BODIES; POLYMERASE-II;

D O I：

10.15252/embj.201593517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by lipid bilayers. These compartments are implicated in a wide range of cellular activities, and they have been variously described as bodies, granules, or organelles. Recent evidence suggests that a liquid-liquid phase separation (LLPS) process may drive their formation, possibly justifying the unifying term "droplet organelle". A veritable deluge of recent publications points to the importance of low-complexity proteins and RNA in determining the physical properties of phase-separated structures. Many of the proteins linked to such structures are implicated in human diseases, such as amyotrophic lateral sclerosis (ALS). We provide an overview of the organizational principles that characterize putative "droplet organelles" in healthy and diseased cells, connecting protein biochemistry with cell physiology.

引用

页码：1603 / 1612

页数：10

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