A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

被引：253

作者：

Hayler, John D. ^{[1
]}

Leahy, David K. ^{[2
]}

Simmons, Eric M. ^{[3
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, API Chem, Stevenage SG1 2NY, Herts, England

[2] Takeda Pharmaceut Int, Proc Chem, Cambridge, MA 02139 USA

[3] Bristol Myers Squibb Co, Chem & Synthet Dev, 1 Squibb Dr, New Brunswick, NJ 08903 USA

来源：

ORGANOMETALLICS | 2019年 / 38卷 / 01期

关键词：

CROSS-COUPLING REACTIONS; ASYMMETRIC HYDROGENATION; C-N; NICKEL CATALYSIS; ARYL HALIDES; SCALE-UP; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; EFFICIENT;

D O I：

10.1021/acs.organomet.8b00566

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

As companies grow ever more mindful of the sustainability aspects of their products and supply chains, an increasing focus on the environmental impact of pharmaceutical manufacture spurs innovation from chemists who support this industry. Metal catalysis has the potential to greatly enhance the sustainability of pharmaceutical products, leading to shorter and more efficient synthetic routes and more direct access to single stereoisomeric products. This perspective article seeks to highlight a number of important considerations for the design of new and improved sustainable metal-catalyzed transformations in order to facilitate rapid adoption by the pharmaceutical industry.

引用

页码：36 / 46

页数：11

共 76 条

[41] PALLADIUM(O)-CATALYZED CROSS-COUPLING REACTION OF ALKOXYDIBORON WITH HALOARENES - A DIRECT PROCEDURE FOR ARYLBORONIC ESTERS [J].

ISHIYAMA, T ;

MURATA, M ;

MIYAURA, N .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (23) :7508-7510

[42] Using the Right Green Yardstick: Why Process Mass intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes [J].

Jimenez-Gonzalez, Concepcion ;

Ponder, Celia S. ;

Broxterman, Quirinus B. ;

Manley, Julie B. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (04) :912-917

[43] Industrial-scale synthesis and applications of asymmetric hydrogenation catalysts [J].

Johnson, Nicholas B. ;

Lennon, Ian C. ;

Moran, Paul H. ;

Ramsden, James A. .

ACCOUNTS OF CHEMICAL RESEARCH, 2007, 40 (12) :1291-1299

[44] Reductive Cross-Coupling Reactions between Two Electrophiles [J].

Knappke, Christiane E. I. ;

Grupe, Sabine ;

Gaertner, Dominik ;

Corpet, Martin ;

Gosmini, Corinne ;

Jacobi von Wangelin, Axel .

CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (23) :6828-6842

[45] ASYMMETRIC HYDROGENATION [J].

KNOWLES, WS .

ACCOUNTS OF CHEMICAL RESEARCH, 1983, 16 (03) :106-112

[46] Efficient and Scalable Enantioselective Synthesis of a CGRP Antagonist [J].

Leahy, David K. ;

Fan, Yu ;

Desai, Lopa V. ;

Chan, Collin ;

Zhu, Jason ;

Luo, Guanglin ;

Chen, Ling ;

Hanson, Ronald L. ;

Sugiyama, Masano ;

Rosner, Thorsten ;

Cuniere, Nicolas ;

Guo, Zhiwei ;

Hsiao, Yi ;

Gao, Qi .

ORGANIC LETTERS, 2012, 14 (18) :4938-4941

[47] A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates [J].

Leonard, John ;

Blacker, A. John ;

Marsden, Stephen P. ;

Jones, Martin F. ;

Mulholland, Keith R. ;

Newton, Rebecca .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2015, 19 (10) :1400-1410

[48] Evolving Green Chemistry Metrics into Predictive Tools for Decision Making and Benchmarking Analytics [J].

Li, Jun ;

Albrecht, Jacob ;

Borovika, Alina ;

Eastgate, Martin D. .

ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2018, 6 (01) :1121-1132

[49] A data-driven strategy for predicting greenness scores, rationally comparing synthetic routes and benchmarking PMI outcomes for the synthesis of molecules in the pharmaceutical industry [J].

Li, Jun ;

Simmons, Eric M. ;

Eastgate, Martin D. .

GREEN CHEMISTRY, 2017, 19 (01) :127-139

[50] Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals [J].

Magano, Javier ;

Dunetz, Joshua R. .

CHEMICAL REVIEWS, 2011, 111 (03) :2177-2250

← 1 2 3 4 5 6 7 8 →