A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

被引：253

作者：

Hayler, John D. ^{[1
]}

Leahy, David K. ^{[2
]}

Simmons, Eric M. ^{[3
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, API Chem, Stevenage SG1 2NY, Herts, England

[2] Takeda Pharmaceut Int, Proc Chem, Cambridge, MA 02139 USA

[3] Bristol Myers Squibb Co, Chem & Synthet Dev, 1 Squibb Dr, New Brunswick, NJ 08903 USA

来源：

ORGANOMETALLICS | 2019年 / 38卷 / 01期

关键词：

CROSS-COUPLING REACTIONS; ASYMMETRIC HYDROGENATION; C-N; NICKEL CATALYSIS; ARYL HALIDES; SCALE-UP; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; EFFICIENT;

D O I：

10.1021/acs.organomet.8b00566

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

As companies grow ever more mindful of the sustainability aspects of their products and supply chains, an increasing focus on the environmental impact of pharmaceutical manufacture spurs innovation from chemists who support this industry. Metal catalysis has the potential to greatly enhance the sustainability of pharmaceutical products, leading to shorter and more efficient synthetic routes and more direct access to single stereoisomeric products. This perspective article seeks to highlight a number of important considerations for the design of new and improved sustainable metal-catalyzed transformations in order to facilitate rapid adoption by the pharmaceutical industry.

引用

页码：36 / 46

页数：11

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