Crystal Engineering in Continuous Plug-Flow Crystallizers

被引:71
作者
Besenhard, Maximilian O. [1 ]
Neugebauer, Peter [2 ]
Scheibelhofer, Otto [1 ]
Khinast, Johannes G. [1 ,2 ]
机构
[1] RCPE, A-8010 Graz, Austria
[2] Graz Univ Technol, Inst Proc & Particle Engn, A-8010 Graz, Austria
基金
奥地利科学基金会;
关键词
BATCH COOLING CRYSTALLIZATION; DIRECT NUCLEATION CONTROL; D-MANNITOL; TAYLOR FLOW; PRESSURE-DROP; FINES REMOVAL; MULTIOBJECTIVE OPTIMIZATION; POLYMORPHIC TRANSFORMATION; SEEDED CRYSTALLIZATION; RAMAN-SPECTROSCOPY;
D O I
10.1021/acs.cgd.7b01096
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise control of the crystal size and shape distribution, as well as polymorphic composition. Tubular crystallizers utilizing segmented flow such as the one presented in our work can provide plug flow characteristics, fast heating and cooling, allowing for rapid changes of the supersaturation. This makes them superior for crystal engineering over common crystallizers. Characterization of particle transport, however, revealed that careful selection of process parameters, such as tubing diameter, flow rates, solvents, etc., is crucial to achieve the full benefits of such reactors.
引用
收藏
页码:6432 / 6444
页数:13
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