The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

被引：26

作者：

Aquila, Giorgio ^{[1
]}

Marracino, Luisa ^{[1
]}

Martino, Valeria ^{[1
]}

Calabria, Donato ^{[2
,3
]}

Campo, Gianluca ^{[4
,5
]}

Caliceti, Cristiana ^{[2
,3
]}

Rizzo, Paola ^{[5
,6
,7
]}

机构：

[1] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[2] Univ Bologna, Dept Chem Giacomo Ciamician, Alma Mater Studiorum, Via Selmi 2, I-40126 Bologna, Italy

[3] Univ Bologna, Interdept Ctr Ind Res CIRI Energy & Environm, Alma Mater Studiorum, Bologna, Italy

[4] Azienda Osped Univ Ferrara, Cardiovasc Inst, Cona, Italy

[5] Univ Ferrara, LTTA, Ferrara, Italy

[6] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[7] Maria Cecilia Hosp, GVM Care & Res, ES Hlth Sci Fdn, Cotignola, Italy

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2019年 / 2019卷

关键词：

SMOOTH-MUSCLE-CELLS; LOW-DENSITY-LIPOPROTEIN; POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; RED-YEAST-RICE; DELTA-LIKE; MONOCYTE CHEMOTACTIC PROTEIN-1; VITAMIN-E SUPPLEMENTATION; HUMAN ENDOTHELIAL-CELLS; PLASMA ASCORBIC-ACID;

D O I：

10.1155/2019/5470470

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have been shown to be involved in the processes underlying atherosclerosis, and evidence has been accumulating for the crucial role of Notch receptors in regulating the functions of the diverse cell types involved in atherosclerosis onset and progression. Several classes of nutraceuticals have potential benefits for the prevention and treatment of atherosclerosis and CVDs, some of which could in part be due to their ability to modulate the Notch pathway. In this review, we summarize the current state of knowledge on the role of Notch in vascular health and its modulation by nutraceuticals for the prevention of atherosclerosis and/or treatment of related CVDs.

引用

页数：30

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