Telling bacteria: Do not LytTR

被引：36
作者：
Galperin, Michael Y. [1 ]
机构：
[1] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
来源：
STRUCTURE | 2008年 / 16卷 / 05期
关键词：
D O I：
10.1016/j.str.2008.04.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptional regulators containing the LytTR-type DNA-binding domain control production of virulence factors in several bacterial pathogens. In this issue of Structure, Sidote et al. report the crystal structure of this elusive domain in complex with its DNA target (Sidote et al., 2008).
引用
收藏
页码：657 / 659
页数：3
相关论文
共 8 条
  • [1] The many faces of the helix-turn-helix domain: Transcription regulation and beyond
    Aravind, L
    Anantharaman, V
    Balaji, S
    Babu, MM
    Iyer, LM
    [J]. FEMS MICROBIOLOGY REVIEWS, 2005, 29 (02) : 231 - 262
  • [2] Foster T., 1996, MED MICROBIOLOGY, V4th, P187
  • [3] Structural classification of bacterial response regulators: Diversity of output domains and domain combinations
    Galperin, Michael Y.
    [J]. JOURNAL OF BACTERIOLOGY, 2006, 188 (12) : 4169 - 4182
  • [4] Bacterial response regulators: versatile regulatory strategies from common domains
    Gao, Rong
    Mack, Timothy R.
    Stock, Ann M.
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2007, 32 (05) : 225 - 234
  • [5] Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC
    Lyon, GJ
    Mayville, P
    Muir, TW
    Novick, RP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) : 13330 - 13335
  • [6] The SKHR motif is required for biological function of the VirR response regulator from Clostridium perfringens
    McGowan, S
    O'Connor, JR
    Cheung, JK
    Rood, JI
    [J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (20) : 6205 - 6208
  • [7] A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family
    Nikolskaya, AN
    Galperin, MY
    [J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (11) : 2453 - 2459
  • [8] Late stage antibacterial drugs in the clinical pipeline
    Projan, Steve J.
    Bradford, Patricia A.
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (05) : 441 - 446
1