Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease

被引：127

作者：

Rasgon, Natalie L. ^{[1
]}

Kenna, Heather A. ^{[1
]}

Wroolie, Tonita E. ^{[1
]}

Kelley, Ryan ^{[2
]}

Silverman, Daniel ^{[3
]}

Brooks, John ^{[4
]}

Williams, Katherine E. ^{[1
]}

Powers, Bevin N. ^{[1
]}

Hallmayer, Joachim

Reiss, Allan ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford Ctr Neurosci Womens Hlth, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA

[3] Univ Calif Los Angeles, Dept Nucl Med, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Insulin resistance; Postmenopausal women; Alzheimer's disease; Hippocampal volume; APOE-epsilon; 4; Dementia risk; APOLIPOPROTEIN-E GENOTYPE; AMYLOID PRECURSOR PROTEIN; COGNITIVE FUNCTION; GLUCOSE-TOLERANCE; BRAIN ATROPHY; ELDERLY POPULATION; MEMORY; DEMENTIA; HYPERINSULINEMIA; METABOLISM;

D O I：

10.1016/j.neurobiolaging.2009.12.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50-65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-epsilon 4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1942 / 1948

页数：7

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