A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics

被引：220

作者：

Nasajpour, Amir ^{[1
,2
]}

Ansari, Sahar ^{[3
]}

Rinoldi, Chiara ^{[1
,2
,4
]}

Rad, Afsaneh Shahrokhi ^{[1
,2
]}

Aghaloo, Tara ^{[5
]}

Shin, Su Ryon ^{[1
,2
,6
]}

Mishra, Yogendra Kumar ^{[7
]}

Adelung, Rainer ^{[7
]}

Swieszkowski, Wojciech ^{[4
]}

Annabi, Nasim ^{[1
,2
,6
,8
]}

Khademhosseini, Ali ^{[1
,2
,6
,9
,10
]}

Moshaverinia, Alireza ^{[3
]}

Tamayol, Ali ^{[1
,2
,6
,11
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA

[2] MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont, Weintraub Ctr Reconstruct Biotechnol, Los Angeles, CA 90095 USA

[4] Warsaw Univ Technol, Fac Mat Sci & Engn, Mat Design Div, 141 Woloska Str, PL-02507 Warsaw, Poland

[5] Univ Calif Los Angeles, Sch Dent, Div Diagnost & Surg Sci, Los Angeles, CA 90095 USA

[6] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[7] Univ Kiel, Funct Nanomat Inst Mat Sci, Kaiserstr 2, D-24143 Kiel, Germany

[8] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[9] King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21569, Saudi Arabia

[10] Konkuk Univ, Dept Bioind Technol, Coll Anim Biosci & Technol, Seoul, South Korea

[11] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2018年 / 28卷 / 03期

基金：

美国国家卫生研究院;

关键词：

electrospinning; guided tissue regeneration; osteoconductive; periodontal regeneration; zinc oxide; GUIDED BONE REGENERATION; MATERIALS PERSPECTIVE; BARRIER MEMBRANES; TISSUE; SCAFFOLD; ZNO; PROLIFERATION; NANOPARTICLES; DEGRADATION; IMPLANTS;

D O I：

10.1002/adfm.201703437

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.

引用

页数：8

共 32 条

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