Addition of High-Dose Cytarabine to Fludarabine-Based Conditioning for Hematopoietic Stem Cell Transplantation for Treating Fanconi Anemia Patients with Advanced Myeloid Malignancy: A Single-Center Experience and Literature Review

被引：4

作者：

Aoki, Takahiro ^{[1
]}

Koh, Katsuyoshi ^{[1
]}

Ikeda, Yuhachi ^{[1
]}

Sekinaka, Yujin ^{[1
]}

Akiyama, Kosuke ^{[1
]}

Mori, Makiko ^{[1
]}

Arakawa, Yuki ^{[1
]}

Hanada, Ryoji ^{[1
]}

机构：

[1] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 09期

关键词：

High-dose cytarabine; Fludarabine-based conditioning; Hematopoietic stem cell transplantation; Fanconi anemia; Acute leukemia; BONE-MARROW-TRANSPLANTATION; MYELODYSPLASTIC SYNDROME; ALTERNATIVE DONORS; ACUTE-LEUKEMIA; CHILDREN; REGIMEN; CYCLOPHOSPHAMIDE; CHEMOTHERAPY;

D O I：

10.1016/j.bbmt.2016.05.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The complication of Fanconi anemia (FA) with acute leukemia is rare and challenging to treat because of high relapse rates, despite the improved outcome of hematopoietic stem cell transplantation with fludarabine-based conditioning for treating FA patients with hematological abnormalities. We added high dose cytarabine to fludarabine-based conditioning to promote an enhanced antitumor effect and successfully subjected 4 patients with FA, including 3 with acute leukemia, to hematopoietic stem cell transplantation. All patients remain alive without treatment-related mortality or evidence of disease. Adding high-dose cytarabine to fludarabine-based conditioning may be tolerable and effective for treating FA patients with acute leukemia. (C) 2016 American Society for Blood and Marrow Transplantation.

引用

页码：1725 / 1728

页数：4

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