Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain

被引：15
作者：
Thiriet, N [1 ]
Jayanthi, S [1 ]
McCoy, M [1 ]
Ladenheim, B [1 ]
Cadet, JL [1 ]
机构：
[1] NIDA, Mol Neuropsychiat Sect, Abuse Intramural Res Program, Baltimore, MD 21224 USA
来源：
MOLECULAR BRAIN RESEARCH | 2001年 / 90卷 / 02期
关键词：
methamphetamine; gene expression; c-myc; L-myc; apoptosis;
D O I：
10.1016/S0169-328X(01)00093-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.
引用
收藏
页码：202 / 204
页数：3
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