Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain

被引：15

作者：

Thiriet, N ^{[1
]}

Jayanthi, S ^{[1
]}

McCoy, M ^{[1
]}

Ladenheim, B ^{[1
]}

Cadet, JL ^{[1
]}

机构：

[1] NIDA, Mol Neuropsychiat Sect, Abuse Intramural Res Program, Baltimore, MD 21224 USA

来源：

MOLECULAR BRAIN RESEARCH | 2001年 / 90卷 / 02期

关键词：

methamphetamine; gene expression; c-myc; L-myc; apoptosis;

D O I：

10.1016/S0169-328X(01)00093-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.

引用

页码：202 / 204

页数：3

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