Intermediate Filaments and Polarization in the Intestinal Epithelium

被引：37

作者：

Coch, Richard A. ^{[1
]}

Leube, Rudolf E. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Mol & Cellular Anat, Wendlingweg 2, D-52074 Aachen, Germany

来源：

CELLS | 2016年 / 5卷 / 03期

关键词：

keratin; cytokeratin; endotube; brush border; C. elegans apical junction; desmosome; gamma-tubulin ring complex; atypical protein kinase C; PAR proteins; NEMATODE CAENORHABDITIS-ELEGANS; BRUSH-BORDER; C-ELEGANS; GAMMA-TUBULIN; TERMINAL WEB; MICROTUBULE ORGANIZATION; KERATIN EXPRESSION; JUNCTION FORMATION; BARRIER FUNCTION; BINDING PROTEIN;

D O I：

10.3390/cells5030032

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. This is particularly apparent in the intestinal epithelium, in which the intermediate filament network is localized below the apical terminal web region and is anchored to the apical junction complex. This arrangement is conserved from the nematode Caenorhabditis elegans to humans. The review summarizes compositional, morphological and functional features of the polarized intermediate filament cytoskeleton in intestinal cells of nematodes and mammals. We emphasize the cross talk of intermediate filaments with the actin- and tubulin-based cytoskeleton. Possible links of the intermediate filament system to the distribution of apical membrane proteins and the cell polarity complex are highlighted. Finally, we discuss how these properties relate to the establishment and maintenance of polarity in the intestine.

引用

页数：18

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