DESIGN, SYNTHESIS AND EVALUATION OF NITRIC OXIDE-RELEASING DERIVATIVES OF N-(n-BUTYL)MATRINIC ACID AND N-(n-BUTYL)MATRINOL AS ANTI-HEPATOCELLULAR CARCINOMA AGENTS

被引：4

作者：

Wu, Ya-Xian ^{[1
]}

Huang, Jun-Kai ^{[1
]}

Gao, Lei-Lei ^{[1
]}

He, Li-Qin ^{[1
]}

Huang, Peng ^{[1
]}

Wang, Xiao-Shan ^{[1
]}

机构：

[1] Anhui Univ Chinese Med, Coll Pharm, Hefei 230012, Peoples R China

来源：

HETEROCYCLES | 2015年 / 91卷 / 02期

关键词：

Matrine; N-n-Butylmatnnic Acid; N-n-Butylmatrinol; Furoxan; Anti-Hepatocarcinoma Activity; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; IN-VITRO; CANCER; MATRINE; CELLS; VIVO;

D O I：

10.3987/COM-14-13144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel furoxan-based derivatives of N-n-butyl matrinic acid (9 a-m) and N-n-butyl matrinol (10a-m) were synthesized and their anti-human hepatocellular carcinoma (HCC) activities were evaluated. All derivatives displayed potential inhibition of HepG2 cell proliferation. Among these derivatives, compounds 9a-f, 9j and 10b, 10g-i (IC50: 0.69-4.66 mu M) were superior to 5-FU (IC50: 5.82 mu M). The further study showed that compounds 9a, 9c and 9f had higher antiproliferative activity on human hepatocellular carcinoma cells Bel-7402 (IC50: 2.55-3.26 mu M) and SMMC-7721 (IC50: 5.26-5.79 mu M).

引用

页码：301 / 312

页数：12

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