The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

被引：58

作者：

Smirnova, E ^{[1
]}

Toueille, M ^{[1
]}

Markkanen, E ^{[1
]}

Hübscher, U ^{[1
]}

机构：

[1] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

来源：

BIOCHEMICAL JOURNAL | 2005年 / 389卷

关键词：

DNA glycosylase; DNA ligase 1; DNA polymerase beta; Flap endonuclease 1 (Fen1); proliferating-cell nuclear antigen (PCNA); Rad9-Rad1-Hus1 complex (9-1-1 complex);

D O I：

10.1042/BJ20050211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease I now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.

引用

页码：13 / 17

页数：5

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