Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment

被引：11
|
作者：
Jay-Gerin, J-P [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Sci Sante, Dept Med Nucl & Radiobiol, 3001,12e Ave Nord, Sherbrooke, PQ J1H 5N4, Canada
来源：
CANCER RADIOTHERAPIE | 2020年 / 24卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Liquid water; Radiolysis; Chemical yield; Hydronium ion (H3O+); pH; Acid spike; Monte Carlo track chemistry simulation; FLASH radiotherapy; HYDROGEN-PEROXIDE; HIGH-INTENSITY; RADIOLYSIS; WATER; PH; CELLS;
D O I：
10.1016/j.canrad.2019.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Monte Carlo simulations of gamma/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：332 / 334
页数：3
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