A case report of tongue metastasis from lung squamous cell carcinoma and literature review

被引：5

作者：

Cheng, Xiaolong ^{[1
]}

Hu, Zhenli ^{[2
]}

Han, Yi-ping ^{[2
]}

Bai, Chong ^{[2
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Gen Practice, Shanghai, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Resp Med, Shanghai, Peoples R China

来源：

MEDICINE | 2017年 / 96卷 / 40期

关键词：

gene mutation; literature review; lung squamous cell carcinoma; poor prognose; tongue metastasis; INITIAL PRESENTATION; MUTATIONS; THERAPY;

D O I：

10.1097/MD.0000000000008208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. Patient concers: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. Diagnoses: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. Intervations: We send the biopsy of the lung and the tongue lesions for gene sequencing. Outcomes: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later. Lessons: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.

引用

页数：5