A case report of tongue metastasis from lung squamous cell carcinoma and literature review

被引：5

作者：

Cheng, Xiaolong ^{[1
]}

Hu, Zhenli ^{[2
]}

Han, Yi-ping ^{[2
]}

Bai, Chong ^{[2
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Gen Practice, Shanghai, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Resp Med, Shanghai, Peoples R China

来源：

MEDICINE | 2017年 / 96卷 / 40期

关键词：

gene mutation; literature review; lung squamous cell carcinoma; poor prognose; tongue metastasis; INITIAL PRESENTATION; MUTATIONS; THERAPY;

D O I：

10.1097/MD.0000000000008208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. Patient concers: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. Diagnoses: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. Intervations: We send the biopsy of the lung and the tongue lesions for gene sequencing. Outcomes: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later. Lessons: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.

引用

页数：5

共 22 条

[1]

[Anonymous], 2016, KLIN ONKOL

[2]

Asamura Hisao, 2016, Gan To Kagaku Ryoho, V43, P955

[3] THE PATHOLOGY OF HEAD AND NECK TUMORS - THE OCCULT PRIMARY AND METASTASES TO THE HEAD AND NECK .10. [J].

BATSAKIS, JG .

HEAD & NECK SURGERY, 1981, 3 (05) :409-423

[4] Molecularly targeted therapies for advanced or metastatic non-small-cell lung carcinoma [J].

Bayraktar, Soley ;

Rocha-Lima, Caio M. .

WORLD JOURNAL OF CLINICAL ONCOLOGY, 2013, 4 (02) :29-42

[5] Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers [J].

Jang, Jin Sung ;

Lee, Adam ;

Li, Jun ;

Liyanage, Hema ;

Yang, Yanan ;

Guo, Lixia ;

Asmann, Yan W. ;

Li, Peter W. ;

Erickson-Johnson, Michele ;

Sakai, Yuta ;

Sun, ZhiFu ;

Jeon, Hyo-Sung ;

Hwang, Hayoung ;

Bungum, Aaron O. ;

Edell, Eric S. ;

Simon, Vernadelle A. ;

Kopp, Karla J. ;

Eckloff, Bruce ;

Oliveira, Andre M. ;

Wieben, Eric ;

Aubry, Marie Christine ;

Yi, Eunhee ;

Wigle, Dennis ;

Diasio, Robert B. ;

Yang, Ping ;

Jen, Jin .

SCIENTIFIC REPORTS, 2015, 5

[6]

Jeba Jenifer, 2016, BMJ Case Rep, V2016, DOI 10.1136/bcr-2016-217539

[7] Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance [J].

Jeong, Youngtae ;

Hoang, Ngoc T. ;

Lovejoy, Alexander ;

Stehr, Henning ;

Newman, Aaron M. ;

Gentles, Andrew J. ;

Kong, William ;

Diana Truong ;

Martin, Shanique ;

Chaudhuri, Aadel ;

Heiser, Diane ;

Zhou, Li ;

Say, Carmen ;

Carter, Justin N. ;

Hiniker, Susan M. ;

Loo, Billy W., Jr. ;

West, Robert B. ;

Beachy, Philip ;

Alizadeh, Ash A. ;

Diehn, Maximilian .

CANCER DISCOVERY, 2017, 7 (01) :86-101

[8] Anterior tongue metastasis from lung cancer [J].

Kurt, Mevlut ;

Bulut, Nilufer ;

Aksoy, Serean ;

Kosemehmetoglu, Kemal ;

Kars, Ayse .

SOUTHERN MEDICAL JOURNAL, 2006, 99 (07) :784-785

[9] Treating patients with ALK-positive non-small cell lung cancer: latest evidence and management strategy [J].

Liao, Bin-Chi ;

Lin, Chia-Chi ;

Shih, Jin-Yuan ;

Yang, James Chih-Hsin .

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2015, 7 (05) :274-290

[10]

Majumder KR, 2015, CLINICOPATHOL PRESEN, V24, P787

← 1 2 3 →