HDAC6:: a key regulator of cytoskeleton, cell migration and cell-cell interactions

被引：402
|
作者：
Valenzuela-Fernandez, Agustin [2 ,3 ]
Cabrero, J. Roman [1 ]
Serrador, Juan M. [4 ]
Sanchez-Madrid, Francisco [1 ,4 ]
机构：
[1] Hosp Univ La Princesa, Serv Immunol, Madrid, Spain
[2] Univ La Laguna, Dept Med Fis & Farmacol, Fac Med, Tenerife, Spain
[3] Univ La Laguna, ITB, Tenerife, Spain
[4] Ctr Nacl Invest Cardiovasc, Dept Biol Vasc & Inflamac, Madrid 28029, Spain
来源：
TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 06期
关键词：
D O I：
10.1016/j.tcb.2008.04.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetyllase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.
引用
收藏
页码：291 / 297
页数：7
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