Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins?

被引：33

作者：

Sessa, WC ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, Boyer Ctr Mol Med, New Haven, CT 06536 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1016/S1471-4914(01)01985-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Statin-based drugs are the mainstay of therapy for coronary artery disease. Recent insights into the cellular mechanisms of this class of drugs suggest that modulation of nitric oxide synthesis contributes to their beneficial actions. These effects are independent of their lipid-lowering effects and result in enhanced nitric oxide release.

引用

页码：189 / 191

页数：3

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