Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats

被引：20
作者：
Blank, Martina [1 ,2 ,3 ]
Werenicz, Aline [1 ,3 ]
Velho, Luciana Azevedo [1 ]
Pinto, Diana F. [1 ]
Fedi, Ana Claudia [1 ]
Lopes, Mark William [4 ]
Peres, Tanara Vieira [4 ]
Leal, Rodrigo Bainy [4 ]
Dornelles, Arethuza S. [1 ,3 ]
Roesler, Rafael [1 ,2 ,3 ]
机构：
[1] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, BR-90050170 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Univ Hosp, Expt Res Ctr, Canc & Neurobiol Lab,CPE,HCPA, BR-90035003 Porto Alegre, RS, Brazil
[3] Natl Inst Translat Med, INCT, TM, BR-90035003 Porto Alegre, RS, Brazil
[4] Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil
来源：
NEUROSCIENCE LETTERS | 2015年 / 594卷
关键词：
Sodium butyrate; Histone deacetylase; Inhibitory avoidance; Epigenetics; Memory consolidation; EPIGENETIC MECHANISMS; ACETYLATION; HIPPOCAMPUS; CHROMATIN; MODEL; MODULATION; PROTEINS; DEFICITS; MICE;
D O I：
10.1016/j.neulet.2015.03.059
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：76 / 81
页数：6
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