Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats

被引：20

作者：

Blank, Martina ^{[1
,2
,3
]}

Werenicz, Aline ^{[1
,3
]}

Velho, Luciana Azevedo ^{[1
]}

Pinto, Diana F. ^{[1
]}

Fedi, Ana Claudia ^{[1
]}

Lopes, Mark William ^{[4
]}

Peres, Tanara Vieira ^{[4
]}

Leal, Rodrigo Bainy ^{[4
]}

Dornelles, Arethuza S. ^{[1
,3
]}

Roesler, Rafael ^{[1
,2
,3
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, BR-90050170 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Univ Hosp, Expt Res Ctr, Canc & Neurobiol Lab,CPE,HCPA, BR-90035003 Porto Alegre, RS, Brazil

[3] Natl Inst Translat Med, INCT, TM, BR-90035003 Porto Alegre, RS, Brazil

[4] Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil

来源：

NEUROSCIENCE LETTERS | 2015年 / 594卷

关键词：

Sodium butyrate; Histone deacetylase; Inhibitory avoidance; Epigenetics; Memory consolidation; EPIGENETIC MECHANISMS; ACETYLATION; HIPPOCAMPUS; CHROMATIN; MODEL; MODULATION; PROTEINS; DEFICITS; MICE;

D O I：

10.1016/j.neulet.2015.03.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：76 / 81

页数：6

共 32 条

[1] Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice:: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration [J].

Alarcón, JM ;

Malleret, G ;

Touzani, K ;

Vronskaya, S ;

Ishii, S ;

Kandel, ER ;

Barco, A .

NEURON, 2004, 42 (06) :947-959

[2] Hot topics in epigenetic mechanisms of aging: 2011 [J].

Berdasco, Maria ;

Esteller, Manel .

AGING CELL, 2012, 11 (02) :181-186

[3] Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus [J].

Blank, Martina ;

Dornelles, Arethuza S. ;

Werenicz, Aline ;

Velho, Luciana A. ;

Pinto, Diana F. ;

Fedi, Ana Claudia ;

Schroeder, Nadja ;

Roesler, Rafael .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2014, 111 :1-8

[4] RETRACTED: Detection of Histone Acetylation Levels in the Dorsal Hippocampus Reveals Early Tagging on Specific Residues of H2B and H4 Histones in Response to Learning (Retracted Article) [J].

Bousiges, Olivier ;

Neidl, Romain ;

Majchrzak, Monique ;

Muller, Marc-Antoine ;

Barbelivien, Alexandra ;

de Vasconcelos, Anne Pereira ;

Schneider, Anne ;

Loeffler, Jean-Philippe ;

Cassel, Jean-Christophe ;

Boutillier, Anne-Laurence .

PLOS ONE, 2013, 8 (03)

[5]

Bredy T.W., 2008, LEARN MEM, V15

[6] Shaping the learning curve: epigenetic dynamics in neural plasticity [J].

Bronfman, Zohar Z. ;

Ginsburg, Simona ;

Jablonka, Eva .

FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2014, 8

[7] HDACi - Targets beyond chromatin [J].

Buchwald, Marc ;

Kraemer, Oliver H. ;

Heinzel, Thorsten .

CANCER LETTERS, 2009, 280 (02) :160-167

[8] Reassessing the Effects of Histone Deacetylase Inhibitors on Hippocampal Memory and Cognitive Aging [J].

Castellano, James F. ;

Fletcher, Bonnie R. ;

Patzke, Holger ;

Long, Jeffrey M. ;

Sewal, Angila ;

Kim, David H. ;

Kelley-Bell, Bennett ;

Rapp, Peter R. .

HIPPOCAMPUS, 2014, 24 (08) :1006-1016

[9] Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus [J].

Castellano, James F. ;

Fletcher, Bonnie R. ;

Kelley-Bell, Bennett ;

Kim, David H. ;

Gallagher, Michela ;

Rapp, Peter R. .

PLOS ONE, 2012, 7 (03)

[10] MEMORY IMPAIRMENT INDUCED BY BRAIN IRON OVERLOAD IS ACCOMPANIED BY REDUCED H3K9 ACETYLATION AND AMELIORATED BY SODIUM BUTYRATE [J].

da Silva, P. F. ;

Garcia, V. A. ;

Dornelles, A. da S. ;

da Silva, V. K. ;

Maurmann, N. ;

Portal, B. C. D. ;

Ferreira, R. D. P. ;

Piazza, F. C. ;

Roesler, R. ;

Schroeder, N. .

NEUROSCIENCE, 2012, 200 :42-49

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