A New Polyoxygenated Triterpene and Two New Aeginetic Acid Quinovosides from the Roots of Rehmannia glutinosa

被引：23

作者：

Lee, So Young ^{[1
,2
]}

Kim, Ju Sun ^{[1
,2
]}

Choi, Ran Joo ^{[1
,2
]}

Kim, Yeong Shik ^{[1
,2
]}

Lee, Je-Hyun ^{[3
]}

Kang, Sam Sik ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Dongguk Univ, Dept Korean Med, Gyeongju Si 780714, Gyeongbuk, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 06期

关键词：

Rehmannia glutinosa; Scrophulariaceae; polyoxygenated triterpene; glutinolic acid; aeginetic acid quinovoside; WATER-SOLUBLE CONSTITUENTS; ABSOLUTE STEREOSTRUCTURES; MONOTERPENE GLUCOSIDE; IRIDOID GLYCOSIDES; IONONE GLUCOSIDES; REHMAGLUTIN-A; INDICA-LINN; DRIED ROOT; RADIX; SAPONINS;

D O I：

10.1248/cpb.59.742

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new minor polyoxygenated triterpene named glutinolic acid (1) and two new aeginetic acid quinovosides (2,3) were isolated from the roots of Rehmannia glutinosa LIBOSCH. (Scrophulariaceae) cultivated in Gunwi-gun, Korea. The structures of these compounds were established as 3 alpha,19 alpha,20 beta,24,30-pentahydroxyurs-12-en-28-oic acid (1, glutinolic acid), aeginetic acid 5-O-beta-D-quinovoside (2) and aeginetoyl ajugol 5 ''-O-beta-D-quinovoside (3) on the basis of chemical and spectroscopic evidence.

引用

页码：742 / 746

页数：5

共 57 条

[1] TRITERPENOIDAL CONSTITUENTS OF UNCARIA FLORIDA VIDAL [J].

AIMI, N ;

LIKHITWITAYAWUID, K ;

GOTO, J ;

PONGLUX, D ;

HAGINIWA, J ;

SAKAI, SI .

TETRAHEDRON, 1989, 45 (13) :4125-4134

[2]

AMIMOTO K, 1993, CHEM PHARM BULL, V41, P39, DOI 10.1248/cpb.41.39

[3]

Anh NTH, 2003, PHARMAZIE, V58, P593

[4]

[Anonymous], 2000, The Medicinal Plants of Korea

[5] MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .32. PENTACYCLIC TRITERPENES [J].

BUDZIKIEWICZ, H ;

WILSON, JM ;

DJERASSI, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (22) :3688-&

[6] 3α,24-dihydroxy-urs-12-en-28-oic acid from Verbena officinalis [J].

Deepak, M ;

Handa, SS .

PHYTOCHEMISTRY, 1998, 49 (01) :269-271

[7]

DIGHE SS, 1977, INDIAN J CHEM B, V15, P546

[8]

DIGHE SS, 1974, INDIAN J CHEM, V12, P413

[9]

ENDO T, 1979, CHEM PHARM BULL, V27, P2807

[10] SYNTHESIS OF (+)-(5S,6S)-AZAFRIN METHYL-ESTER - ABSOLUTE-CONFIGURATION OF AEGINETIC ACID AND OF FURTHER VICINAL APOCAROTENE-DIOLS [J].

ESCHENMOSER, W ;

UEBELHART, P ;

EUGSTER, CH .

HELVETICA CHIMICA ACTA, 1982, 65 (01) :353-364

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