Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

被引：82

作者：

Cellurale, Cristina

Sabio, Guadalupe

Kennedy, Norman J.

Das, Madhumita

Barlow, Marissa

Sandy, Peter ^{[2
,3
,4
]}

Jacks, Tyler ^{[2
,3
,4
]}

Davis, Roger J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Mol Med, Worcester, MA 01605 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

[4] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2011年 / 31卷 / 07期

基金：

美国国家卫生研究院;

关键词：

SIGNAL-TRANSDUCTION PATHWAY; TRANSCRIPTION FACTOR SNAIL; E-CADHERIN; GLIOBLASTOMA CELLS; MAP KINASE; K-RAS; JNK; EXPRESSION; CANCER; MICE;

D O I：

10.1128/MCB.01122-10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-Jun NH2-terminal kinase (JNK) signal transduction pathway causes increased gene expression mediated, in part, by members of the activating transcription factor protein (AP1) group. JNK is therefore implicated in the regulation of cell growth and cancer. To test the role of JNK in Ras-induced tumor formation, we examined the effect of compound ablation of the ubiquitously expressed genes Jnk1 plus Jnk2. We report that JNK is required for Ras-induced transformation of p53-deficient primary cells in vitro. Moreover, JNK is required for lung tumor development caused by mutational activation of the endogenous KRas gene in vivo. Together, these data establish that JNK plays a key role in Ras-induced tumorigenesis.

引用

收藏

页码：1565 / 1576

页数：12

相关论文

共 50 条

[41] Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells:: A role of c-Jun NH2-terminal kinase 1 [J].

Li, F ;

Meng, L ;

Zhou, JF ;

Xing, H ;

Wang, SX ;

Xu, G ;

Zhu, HS ;

Wang, BB ;

Chen, G ;

Lu, YP ;

Ma, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 335 (04) :1070-1077

[42] Oncogenic Ras Signals through Activation of Both Phosphoinositide 3-Kinase and Rac1 to Induce c-Jun NH2-Terminal Kinase-Mediated, Caspase-Independent Cell Death [J].

Yun, Joo-Yun ;

Kim, Min-Jung ;

Yoon, Chang-Hwan ;

Cha, Hyukjin ;

Yoon, Gyesoon ;

Lee, Su-Jae .

MOLECULAR CANCER RESEARCH, 2009, 7 (09) :1534-1542

[43] c-Jun NH2-TERMINAL KINASE REGULATES LIPOPOLYSACCHARIDE-INDUCED PULMONARY MONONUCLEAR CELL RECRUITMENT VIA CCL2 [J].

Young, Scott K. ;

Arndt, Patrick G. .

EXPERIMENTAL LUNG RESEARCH, 2009, 35 (08) :682-700

[44] c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells [J].

Lorin, Severine ;

Borges, Amelie ;

Dos Santos, Lisandra Ribeiro ;

Souquere, Sylvie ;

Pierron, Gerard ;

Ryan, Kevin M. ;

Codogno, Patrice ;

Djavaheri-Mergny, Mojgan .

CANCER RESEARCH, 2009, 69 (17) :6924-6931

[45] c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study [J].

Hussein, Mostafa ;

Chai, Daniel C. ;

Kyama, Cleophas M. ;

Mwenda, Jason M. ;

Palmer, Stephen S. ;

Gotteland, Jean-Pierre ;

D'Hooghe, Thomas M. .

FERTILITY AND STERILITY, 2016, 105 (03) :815-+

[46] Dexamethasone activates c-Jun NH2-terminal kinase (JNK) which interacts with GR and protects it from ubiquitin-mediated degradation in NSCLC cells [J].

Srivastava, Swati ;

Siddiqui, Shumaila ;

Chowdhury, Sangita ;

Trivedi, Arun Kumar .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 650 :1-8

[47] TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH2-terminal kinase and transcription factor AP-1 [J].

Soond, Surinder M. ;

Terry, Jennifer L. ;

Riches, David W. H. .

FEBS LETTERS, 2006, 580 (19) :4591-4596

[48] Calcium-Sensing Receptor Induced Myocardial Ischemia/Reperfusion Injury via the C-Jun NH2-Terminal Protein Kinase Pathway [J].

Jiang, Chun-Ming ;

Xu, Chang-Qing ;

Mi, Yan ;

Li, Hong-Zhu ;

Wang, Rui ;

Li, Wei-Min .

ACTA CARDIOLOGICA SINICA, 2010, 26 (02) :102-110

[49] Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways [J].

Kovacheva, Ekaterina L. ;

Hikim, Amiya P. Sinha ;

Shen, Ruoqing ;

Sinha, Indranil ;

Sinha-Hikim, Indrani .

ENDOCRINOLOGY, 2010, 151 (02) :628-638

[50] Mild Hypothermia Pretreatment Attenuates Liver Ischemia Reperfusion Injury Through Inhibiting c-Jun NH2-terminal Kinase Phosphorylation in Rats [J].

Wang, W. ;

Xiao, Q. ;

Hu, X-Y. ;

Liu, Z-Z. ;

Zhang, X-J ;

Xia, Z-P. ;

Ye, Q-F. ;

Niu, Y. .

TRANSPLANTATION PROCEEDINGS, 2018, 50 (01) :259-266

← 1 2 3 4 5 →