Benzofuroindole analogues as potent BKCa channel openers

被引：36

作者：

Gormemis, AE ^{[1
]}

Ha, TS ^{[1
]}

Im, I ^{[1
]}

Jung, KY ^{[1
]}

Lee, JY ^{[1
]}

Park, CS ^{[1
]}

Kim, YC ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 10期

关键词：

benzofuroindole; drug design; ion channels; opener; outside-out patches;

D O I：

10.1002/cbic.200400448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toward drugs to treat neuronal damage. The design and synthesis of new, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiological evaluations have been brought about through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352; see scheme). These new channel openers might find therapeutic use in stroke, asthma, hypertension, convulsion, and traumatic brain injury. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1745 / 1748

页数：4

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