Development of degradable and bioactive composite as bone implants by incorporation of mesoporous bioglass into poly(L-lactide)

被引:29
作者
Cao, Liehu [1 ]
Weng, Weizong [1 ]
Chen, Xiao [1 ]
Ding, Yueting [4 ]
Yan, Yonggang [2 ]
Li, Haihang [1 ]
Zhao, Hao [1 ]
Shin, Jung-Woog [3 ]
Wei, Jie [4 ]
Ji, Fang [1 ]
Su, Jiacan [1 ]
机构
[1] Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Trauma, Shanghai 200433, Peoples R China
[2] Sichuan Univ, Coll Phys Sci & Technol, Chengdu 610041, Peoples R China
[3] Inje Univ, Dept Biomed Engn, Gimhae 621749, South Korea
[4] E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomedicial Mat, Shanghai 200237, Peoples R China
基金
上海市自然科学基金; 中国国家自然科学基金;
关键词
Polymer-matrix composites (PMCs); Surface properties; Casting; Microstructures; Cytocompatibility; MECHANICAL-PROPERTIES; CALCIUM-CARBONATE; ACID) COMPOSITES; GLASS SCAFFOLDS; DRUG-DELIVERY; ION RELEASE; STEM-CELLS; IN-VITRO; FABRICATION; DIFFERENTIATION;
D O I
10.1016/j.compositesb.2015.03.034
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Bioactive composites containing mesoporous bioglass (MBG) and poly(L-lactide) (PLLA) for bone regeneration were fabricated by solution casting method. The results showed that the compressive strength and hydrophilicity of the MBG/PLLA composites significantly improved with the increase of MBG content. In addition, the weight loss ratio of the composites in Tris-HC1 solution was obviously enhanced with the increase of MBG content. Moreover, the composite containing MBG could compensate for the decrease of pH value by neutralizing the acidic products from PLLA degradation in the Tris-HCI solution. Furthermore, the MBG/PLLA composites could induce apatite formation on their surfaces after soaked into simulated body fluid (SBF), indicating good bioactivity. In cell culture experiments, the results showed that the composite could enhance cell attachment, proliferation and alkaline phosphatase activity (ALP) of MC3T3-E1 cells, and the improvements were dependent on the MBG content in the composites. In short, the MBG/PLLA biocomposites with improved properties of hydrophilicity, degradability, bioactivity, neutralizing acidic degradable products and good cytocompatibility would be a promising orthopedic implant material for bone repair application. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:454 / 461
页数:8
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