KIM-1 expression in kidney allograft biopsies: Improving the gold standard

被引:8
作者
Abulezz, S. [1 ]
机构
[1] Univ Arkansas Med Sci, Little Rock, AR 72205 USA
关键词
D O I
10.1038/sj.ki.5002772
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft survival.
引用
收藏
页码:522 / 523
页数:2
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共 8 条
  • [1] Correlation between cyclosporine-induced nephrotoxicity in reduced nephron mass and expression of kidney injury molecule-1 and apuaporin-2 gene
    Hong, ME
    Hong, JC
    Stepkowski, S
    Kahan, BD
    [J]. TRANSPLANTATION PROCEEDINGS, 2005, 37 (10) : 4254 - 4258
  • [2] Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    Ichimura, T
    Bonventre, JV
    Bailly, V
    Wei, H
    Hession, CA
    Cate, RL
    Sanicola, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (07) : 4135 - 4142
  • [3] Kidney NGAL is a novel early marker of acute injury following transplantation
    Mishra, Jaya
    Ma, Qing
    Kelly, Caitlin
    Mitsnefes, Mark
    Mori, Kiyoshi
    Barasch, Jonathan
    Devarajan, Prasad
    [J]. PEDIATRIC NEPHROLOGY, 2006, 21 (06) : 856 - 863
  • [4] Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation
    Parikh, C. R.
    Jani, A.
    Mishra, J.
    Ma, Q.
    Kelly, C.
    Barasch, J.
    Edelstein, C. L.
    Devarajan, P.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (07) : 1639 - 1645
  • [5] Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
    Perez-Rojas, Jazmin
    Blanco, Jorge A.
    Cruz, Cristino
    Trujillo, Joyce
    Vaidya, Vishal S.
    Uribe, Norma
    Bonventre, Joseph V.
    Gamba, Gerardo
    Bobadilla, Norma A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2007, 292 (01) : F131 - F139
  • [6] Detection of subclinical tubular injury after renal transplantation:: Comparison of urine protein analysis with allograft histopathology
    Schaub, Stefan
    Mayr, Michael
    Hoenger, Gideon
    Bestland, Jennifer
    Steiger, Juerg
    Regeniter, Axel
    Mihatsch, Michael J.
    Wilkins, John A.
    Rush, David
    Nickerson, Peter
    [J]. TRANSPLANTATION, 2007, 84 (01) : 104 - 112
  • [7] Tubular kidney injury molecule-1 (KIM-1) in human renal disease
    van Timmeren, M. M.
    van den Heuvel, M. C.
    Bailly, V.
    Bakker, S. J. L.
    van Goor, H.
    Stegeman, C. A.
    [J]. JOURNAL OF PATHOLOGY, 2007, 212 (02) : 209 - 217
  • [8] Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury
    Zhang, P. L.
    Rothblum, L. I.
    Han, W. K.
    Blasick, T. M.
    Potdar, S.
    Bonventre, J. V.
    [J]. KIDNEY INTERNATIONAL, 2008, 73 (05) : 608 - 614