Neuroprotection against hypoxia-ischemia by insulin-like growth factor-I (IGF-I)

被引:1
作者
Smith, PF [1 ]
机构
[1] Univ Otago, Dept Pharmacol & Toxicol, Sch Med Sci, Dunedin, New Zealand
关键词
hypoxia-ischemia; insulin-like growth factor-I;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that has been investigated as a potential neuroprotective drug for the treatment of stroke and other forms of neural damage. Preclinical studies over the last decade have demonstrated that IGF-I and some of its fragments can protect against neuronal and glial cell degeneration in animal models of stroke such as hypoxia-ischemia. Although the results to date are encouraging, the size of the IGF-I molecule has proved problematic and has led researchers to investigate routes of administration that bypass the blood-brain barrier, such as intranasal application, or to focus on fragments of IGF-I, such as the N-terminal peptide Gly-Pro-Glut (GPE). Mile the results of these studies have also been positive, systematic dose-response comparisons with recognized neuroprotectants have not yet been published, the time window for therapeutic effects is not yet clear and long-term functional studies have not been conducted.
引用
收藏
页码:1173 / 1177
页数:5
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