Herbal medicines for the treatment of cancer chemotherapy-induced side effects

被引：69
作者：
Ohnishi, Shunsuke [1 ]
Takede, Hiroshi [2 ]
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido 0600812, Japan
[2] Hokkaido Univ, Fac Pharmaceut Sci, Pathophysiol & Therapeut, Sapporo, Hokkaido 0600812, Japan
来源：
FRONTIERS IN PHARMACOLOGY | 2015年 / 6卷
基金：
日本学术振兴会;
关键词：
Kampo; rikkunshito; hangeshashinto; goshajinkigan; chemotherapy-induced side effects; TRADITIONAL JAPANESE MEDICINE; CISPLATIN-INDUCED ANOREXIA; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; HIGH-DOSE CISPLATIN; HANGE-SHASHIN-TO; DES-ACYL GHRELIN; INDUCED NAUSEA; DOUBLE-BLIND; ORAL MUCOSITIS;
D O I：
10.3389/fphar.2015.00014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Accumulating evidence suggests that Japanese herbal medicines, called Kampo, have beneficial effects on cancer chemotherapy induced side effects. Rikkunshito ameliorates cisplatin-induced anorexia through an antagonistic effect on the 5-HT receptors and by increasing the serum ghrelin levels. Hangeshashinto improves irinotecan-induced diarrhea and chemotherapy-induced mucositis by inhibiting the activity of beta-glucuronidase as well as the synthesis of prostaglandin E2. Goshajinkigan prevents oxaliplatin-induced neurotoxicity, possibly through suppressing functional alterations of the transient receptor potential channels. In this review, we will summarize the currently available literature regarding the clinical efficacy and potential mechanisms of Kampo medicines in the treatment of cancer chemotherapy induced side effects.
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页数：5
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共 67 条
[51]   Comparison of an aprepitant regimen with a multiple-day ondansetron regimen, both with dexamethasone, for antiemetic efficacy in high-dose cisplatin treatment [J].
Schmoll, H. J. ;
Aapro, M. S. ;
Poli-Bigelli, S. ;
Kim, H. -K. ;
Park, K. ;
Jordan, K. ;
von Pawel, J. ;
Giezek, H. ;
Ahmed, T. ;
Chan, C. Y. .
ANNALS OF ONCOLOGY, 2006, 17 (06) :1000-1006
[52]   A New Candidate Supporting Drug, Rikkunshito, for the QOL in Advanced Esophageal Cancer Patients with Chemotherapy Using Docetaxel/5-FU/CDDP [J].
Seike, Junichi ;
Sawada, Toru ;
Kawakita, Naoya ;
Yamamoto, Yota ;
Yuasa, Yasuhiro ;
Yamai, Hiromichi ;
Takachi, Hirokazu ;
Yoshida, Takahiro ;
Tangoku, Akira .
INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY, 2011, 2011
[53]   Cancer Statistics, 2014 [J].
Siegel, Rebecca ;
Ma, Jiemin ;
Zou, Zhaohui ;
Jemal, Ahmedin .
CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (01) :9-29
[54]   PROTECTIVE EFFECTS OF KAMPO MEDICINES AND BAICALIN AGAINST INTESTINAL TOXICITY OF A NEW ANTICANCER CAMPTOTHECIN DERIVATIVE, IRINOTECAN HYDROCHLORIDE (CPT-11), IN RATS [J].
TAKASUNA, K ;
KASAI, Y ;
KITANO, Y ;
MORI, K ;
KOBAYASHI, R ;
HAGIWARA, T ;
KAKIHATA, K ;
HIROHASHI, M ;
NOMURA, M ;
NAGAI, E ;
KAMATAKI, T .
JAPANESE JOURNAL OF CANCER RESEARCH, 1995, 86 (10) :978-984
[55]   Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism [J].
Takeda, Hiroshi ;
Sadakane, Chiharu ;
Hattori, Tomohisa ;
Katsurada, Takehiko ;
Ohkawara, Tatsuya ;
Nagai, Koichi ;
Asaka, Masahiro .
GASTROENTEROLOGY, 2008, 134 (07) :2004-2013
[56]  
TATSUTA M, 1993, ALIMENT PHARM THERAP, V7, P459
[57]   THE EFFECTS OF GOSHAJINKIGAN, A HERBAL MEDICINE, ON SUBJECTIVE SYMPTOMS AND VIBRATORY THRESHOLD IN PATIENTS WITH DIABETIC NEUROPATHY [J].
TAWATA, M ;
KURIHARA, A ;
NITTA, K ;
IWASE, E ;
GAN, N ;
ONAYA, T .
DIABETES RESEARCH AND CLINICAL PRACTICE, 1994, 26 (02) :121-128
[58]   The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats [J].
Tominaga, K. ;
Kido, T. ;
Ochi, M. ;
Sadakane, C. ;
Mase, A. ;
Okazaki, H. ;
Yamagami, H. ;
Tanigawa, T. ;
Watanabe, K. ;
Watanabe, T. ;
Fujiwara, Y. ;
Oshitani, N. ;
Arakawa, T. .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 :1-8
[59]   Hypotensive effect of des-acyl ghrelin at nucleus tractus solitarii of rat [J].
Tsubota, Y ;
Owada-Makabe, K ;
Yukawa, K ;
Maeda, M .
NEUROREPORT, 2005, 16 (02) :163-166
[60]   Effects of Goshajinkigan on insulin resistance in patients with type 2 diabetes [J].
Uno, T ;
Ohsawa, I ;
Tokudome, M ;
Sato, Y .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2005, 69 (02) :129-135
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