Herbal medicines for the treatment of cancer chemotherapy-induced side effects

被引：69
作者：
Ohnishi, Shunsuke [1 ]
Takede, Hiroshi [2 ]
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido 0600812, Japan
[2] Hokkaido Univ, Fac Pharmaceut Sci, Pathophysiol & Therapeut, Sapporo, Hokkaido 0600812, Japan
来源：
FRONTIERS IN PHARMACOLOGY | 2015年 / 6卷
基金：
日本学术振兴会;
关键词：
Kampo; rikkunshito; hangeshashinto; goshajinkigan; chemotherapy-induced side effects; TRADITIONAL JAPANESE MEDICINE; CISPLATIN-INDUCED ANOREXIA; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; HIGH-DOSE CISPLATIN; HANGE-SHASHIN-TO; DES-ACYL GHRELIN; INDUCED NAUSEA; DOUBLE-BLIND; ORAL MUCOSITIS;
D O I：
10.3389/fphar.2015.00014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Accumulating evidence suggests that Japanese herbal medicines, called Kampo, have beneficial effects on cancer chemotherapy induced side effects. Rikkunshito ameliorates cisplatin-induced anorexia through an antagonistic effect on the 5-HT receptors and by increasing the serum ghrelin levels. Hangeshashinto improves irinotecan-induced diarrhea and chemotherapy-induced mucositis by inhibiting the activity of beta-glucuronidase as well as the synthesis of prostaglandin E2. Goshajinkigan prevents oxaliplatin-induced neurotoxicity, possibly through suppressing functional alterations of the transient receptor potential channels. In this review, we will summarize the currently available literature regarding the clinical efficacy and potential mechanisms of Kampo medicines in the treatment of cancer chemotherapy induced side effects.
引用
收藏
页数：5
相关论文
共 67 条
[31]   Gosha-jinki-gan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats [J].
Kato, Yoshinori ;
Tateai, Yoshikazu ;
Ohkubo, Misao ;
Saito, Yuka ;
Amagai, Syun-ya ;
Kimura, Yu-suke ;
Iimura, Naohumi ;
Okada, Megumi ;
Matsumoto, Akiko ;
Mano, Yasunari ;
Hirosawa, Iori ;
Ohuchi, Kaori ;
Tajima, Masataka ;
Asahi, Mariko ;
Kotaki, Hajime ;
Yamada, Harumi .
ANTI-CANCER DRUGS, 2014, 25 (01) :39-43
[32]   Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].
Kojima, M ;
Hosoda, H ;
Date, Y ;
Nakazato, M ;
Matsuo, H ;
Kangawa, K .
NATURE, 1999, 402 (6762) :656-660
[33]   Phase 1/2 Clinical Study of Irinotecan and Oral S-1 (IRIS) in Patients with Advanced Gastric Cancer [J].
Komatsu, Yoshito ;
Yuki, Satoshi ;
Fuse, Nozomu ;
Kato, Takashi ;
Miyagishima, Takuto ;
Kudo, Mineo ;
Kunieda, Yasuyuki ;
Tateyama, Miki ;
Wakahama, Osamu ;
Meguro, Takashi ;
Sakata, Yuh ;
Asaka, Masahiro .
ADVANCES IN THERAPY, 2010, 27 (07) :483-492
[34]   Multitargeted Effects of Hangeshashinto for Treatment of Chemotherapy-Induced Oral Mucositis on Inducible Prostaglandin E2 Production in Human Oral Keratinocytes [J].
Kono, Toru ;
Kaneko, Atsushi ;
Matsumoto, Chinami ;
Miyagi, Chika ;
Ohbuchi, Katsuya ;
Mizuhara, Yasuharu ;
Miyano, Kanako ;
Uezono, Yasuhito .
INTEGRATIVE CANCER THERAPIES, 2014, 13 (05) :435-445
[35]   Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induced neuropathy [J].
Kono, Toru ;
Hata, Taishi ;
Morita, Satoshi ;
Munemoto, Yoshinori ;
Matsui, Takanori ;
Kojima, Hiroshi ;
Takemoto, Hiroyoshi ;
Fukunaga, Mutsumi ;
Nagata, Naoki ;
Shimada, Mitsuo ;
Sakamoto, Junichi ;
Mishima, Hideyuki .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 72 (06) :1283-1290
[36]  
Kono Toru, 2010, World J Oncol, V1, P232, DOI 10.4021/wjon263w
[37]   Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer [J].
Kono, Toru ;
Mamiya, Noriaki ;
Chisato, Naoyuki ;
Ebisawa, Yosiaki ;
Yamazaki, Hirotaka ;
Watari, Jiro ;
Yamamoto, Yasuhiro ;
Suzuki, Shigetaka ;
Asama, Toshiyuki ;
Kamiya, Kazunori .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 :1-8
[38]  
Lopez-Castano Fuensanta, 2005, Med Oral Patol Oral Cir Bucal, V10, P412
[39]   Systematic review of basic oral care for the management of oral mucositis in cancer patients [J].
McGuire, Deborah B. ;
Fulton, Janet S. ;
Park, Jumin ;
Brown, Carlton G. ;
Correa, M. Elvira P. ;
Eilers, June ;
Elad, Sharon ;
Gibson, Faith ;
Oberle-Edwards, Loree K. ;
Bowen, Joanne ;
Lalla, Rajesh V. .
SUPPORTIVE CARE IN CANCER, 2013, 21 (11) :3165-3177
[40]   Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat [J].
Mizuno, Keita ;
Kono, Toru ;
Suzuki, Yasuyuki ;
Miyagi, Chika ;
Omiya, Yuji ;
Miyano, Kanako ;
Kase, Yoshio ;
Uezono, Yasuhito .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 125 (01) :91-98
1234567