Herbal medicines for the treatment of cancer chemotherapy-induced side effects

被引：69
作者：
Ohnishi, Shunsuke [1 ]
Takede, Hiroshi [2 ]
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Hokkaido 0600812, Japan
[2] Hokkaido Univ, Fac Pharmaceut Sci, Pathophysiol & Therapeut, Sapporo, Hokkaido 0600812, Japan
来源：
FRONTIERS IN PHARMACOLOGY | 2015年 / 6卷
基金：
日本学术振兴会;
关键词：
Kampo; rikkunshito; hangeshashinto; goshajinkigan; chemotherapy-induced side effects; TRADITIONAL JAPANESE MEDICINE; CISPLATIN-INDUCED ANOREXIA; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; HIGH-DOSE CISPLATIN; HANGE-SHASHIN-TO; DES-ACYL GHRELIN; INDUCED NAUSEA; DOUBLE-BLIND; ORAL MUCOSITIS;
D O I：
10.3389/fphar.2015.00014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Accumulating evidence suggests that Japanese herbal medicines, called Kampo, have beneficial effects on cancer chemotherapy induced side effects. Rikkunshito ameliorates cisplatin-induced anorexia through an antagonistic effect on the 5-HT receptors and by increasing the serum ghrelin levels. Hangeshashinto improves irinotecan-induced diarrhea and chemotherapy-induced mucositis by inhibiting the activity of beta-glucuronidase as well as the synthesis of prostaglandin E2. Goshajinkigan prevents oxaliplatin-induced neurotoxicity, possibly through suppressing functional alterations of the transient receptor potential channels. In this review, we will summarize the currently available literature regarding the clinical efficacy and potential mechanisms of Kampo medicines in the treatment of cancer chemotherapy induced side effects.
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页数：5
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