Cross-reactivity reduced dengue virus 2 vaccine has no cross-protection against heterotypic dengue viruses

被引：0

作者：

Galula, Jedhan U. ^{[1
]}

Yang, Chung-Yu ^{[1
]}

Davis, Brent S. ^{[2
]}

Chang, Gwong-Jen J. ^{[2
]}

Chao, Day-Yu ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Microbiol & Publ Hlth, Taichung 402, Taiwan

[2] Ctr Dis Control & Prevent, Div Vector Borne Dis, US Dept HHS, Ft Collins, CO 80521 USA

来源：

FUTURE VIROLOGY | 2020年 / 15卷 / 02期

关键词：

cross-protection; cross-reactivity reduced; dengue virus; DENV-2; vaccine; epitope modification; neutralizing antibodies; prime-boost; JAPANESE ENCEPHALITIS; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODY; DNA; INFECTION; AG129; SECRETION; EFFICACY; MODEL; IMMUNOGENICITY;

D O I：

10.2217/fvl-2019-0115

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: This study assessed how prime-boost strategies influence the immunogenicity of a cross-reactivity reduced dengue virus 2 vaccine (DENV-2 RD). Materials & methods: Mice were immunized with DENV-2 RD vaccines in a heterologous DNA and virus-like particle (VLP) prime-boost. Elicited antibodies were analyzed for neutralization and protective efficacy against four DENV serotypes. Results: DENV-2 RD DNA-VLP had induced higher and broader levels of total IgG and neutralizing antibodies with statistically significant IgG titers against DENV-2 and -3. Only pups of DENV-2 RD DNA-VLP immunized female mice were fully protected against homotypic DENV challenge and partially protected (60% survival rate) against heterotypic DENV-3 lethal challenge. Conclusion: DENV-2 RD vaccine requires a multivalent format to effectively elicit a balanced and protective immunity across all four DENV serotypes.

引用

页码：79 / 90

页数：12

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