Investigation of EGFR copy-number variations in skin cancers

被引：0
|
作者：
Zhang, Jie [1 ,2 ,3 ]
Zhang, Richu [4 ]
Shao, Yong [1 ,2 ,3 ]
Chen, Bancheng [1 ,2 ,3 ]
Hu, Xiaoping [1 ,2 ,3 ]
Wan, Jun [1 ,3 ,5 ]
Zhang, Chao [1 ,3 ]
Zhang, Wei [1 ,5 ,6 ]
Yu, Bo [1 ,2 ,3 ]
机构：
[1] Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 510632, Guangdong, Peoples R China
[2] Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
[3] Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 510632, Guangdong, Peoples R China
[4] Taizhou Municipal Hosp, Dept Gen Surg, Taizhou, Zhejiang, Peoples R China
[5] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
[6] Jinan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China
来源：
EUROPEAN JOURNAL OF ONCOLOGY | 2011年 / 16卷 / 01期
关键词：
EGFR; copy-number variations (CNVs); basal cell carcinoma (BCC); squamous cell carcinoma (SCC); actinic keratosis (AK); GROWTH-FACTOR RECEPTOR; SQUAMOUS-CELL CARCINOMAS; GEFITINIB SENSITIVITY; GENE AMPLIFICATION; PROTEIN EXPRESSION; LUNG-CANCER; PHASE-II; HEAD; VALIDATION; RECURRENT;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim. The epidermal growth factor receptor (EGFR) family members play a considerable role in carcinogenesis. Copy number variations (CNVs) have been discovered to have phenotypic consequences and to be associated with various types of cancer. CNVs of EGFR were associated with cancer pathogenesis in recent studies. However, few studies were performed in skin cancer. In this study, we aim to examine the CNVs of EGFR in skin samples. Materials and methods. A total of 195 paired-samples including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and actinic keratosis (AK) were included. Real-time PCR was used for the quantification of EGFR copy numbers. Results. CNVs of EGFR showed statistical differences between cancer samples (both SCC and BCC) and normal tissues (p<0.05). Association analysis showed that the frequencies of EGFR's CNVs were correlated with the severity of skin abnormalities (p=0.011). Conclusions. CNVs of EGFR are associated with SCC and BCC but not with AK. Eur. J. Oncol., 16 (1), 15-19, 2011
引用
收藏
页码：15 / 19
页数：5
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