Salivary Gland Pathology in Sjogren's Syndrome

被引：29
作者：
Campos, Joana [1 ]
Hillen, Maarten R. [1 ,2 ]
Barone, Francesca [1 ]
机构：
[1] Univ Birmingham, Ctr Translat Inflammat Res, Inst Inflammat & Ageing, ARUK Ctr Pathogenesis Rheumatoid Arthrit,Queen El, Mindelsohn Way, Birmingham B15 2WB, W Midlands, England
[2] Univ Med Ctr Utrecht, Lab Translat Immunol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2016年 / 42卷 / 03期
基金：
英国医学研究理事会;
关键词：
Primary Sjogren's syndrome; Salivary glands; Histopathology; Autammune disease; HELPER T-CELLS; TERTIARY LYMPHOID STRUCTURES; MESSENGER-RNA EXPRESSION; ECTOPIC GERMINAL-CENTERS; B-CELLS; EPITHELIAL-CELLS; DENDRITIC CELLS; AUTOANTIBODY PRODUCTION; SYNDROME ASSOCIATION; AUTOIMMUNE-DISEASES;
D O I：
10.1016/j.rdc.2016.03.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Primary Sjogren's syndrome (pSS) can be considered a systemic autoimmune disease with a strong organ bias. The involvement of the exocrine glands is prevalent and drives the pathognothonic manifestations of dryness that define the sicca syndrome. The salivary glands also represent the hub of pSS pathology. Elements belonging to both innate and acquired immune responses have been described at this site that contribute to disease establishment and progression. The interaction between those elements and their relative contributions to the clinical manifestations and lymphoma progression largely remain to be addressed.
引用
收藏
页码：473 / +
页数：12
相关论文
共 83 条
  • [11] Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate
    Bombardieri, M
    Barone, F
    Pittoni, V
    Alessandri, C
    Conigliaro, P
    Blades, MC
    Priori, R
    McInnes, IB
    Valesini, G
    Pitzalis, C
    [J]. ARTHRITIS RESEARCH & THERAPY, 2004, 6 (05) : R447 - R456
  • [12] Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome
    Bombardieri, Michele
    Barone, Francesca
    Humby, Frances
    Kelly, Stephen
    McGurk, Mark
    Morgan, Peter
    Challacombe, Stephen
    De Vita, Salvatore
    Valesini, Guido
    Spencer, Jo
    Pitzalis, Costantino
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (07) : 4929 - 4938
  • [13] Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice
    Bombardieri, Michele
    Barone, Francesca
    Lucchesi, Davide
    Nayar, Saba
    van den Berg, Wim B.
    Proctor, Gordon
    Buckley, Christopher D.
    Pitzalis, Costantino
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 189 (07) : 3767 - 3776
  • [14] Whole Stimulated Salivary Flow Correlation With the Pathology of Inflammation and Damage in Minor Salivary Gland Biopsy Specimens From Patients With Primary Sjogren's Syndrome but Not Patients With Sicca
    Bookman, Arthur A. M.
    Shen, Hua
    Cook, Richard J.
    Bailey, Denis
    McComb, R. John
    Rutka, John A.
    Slomovic, Allan R.
    Caffery, Barbara
    [J]. ARTHRITIS AND RHEUMATISM, 2011, 63 (07): : 2014 - 2020
  • [15] Type I IFN signature in primary Sjogren's syndrome patients
    Brkic, Zana
    Versnel, Marjan A.
    [J]. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2014, 10 (04) : 457 - 467
  • [16] Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression
    Brkic, Zana
    Maria, Naomi I.
    van Helden-Meeuwsen, Cornelia G.
    van de Merwe, Joop P.
    van Daele, Paul L.
    Dalm, Virgil A.
    Wildenberg, Manon E.
    Beumer, Wouter
    Drexhage, Hemmo A.
    Versnel, Marjan A.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (05) : 728 - 735
  • [17] Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation
    Buckley, Christopher D.
    Barone, Francesca
    Nayar, Saba
    Benezech, Cecile
    Caamano, Jorge
    [J]. ANNUAL REVIEW OF IMMUNOLOGY VOL 33, 2015, 33 : 715 - 745
  • [18] Is minor salivary gland biopsy more than a diagnostic tool in primary Sjogren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study
    Carubbi, Francesco
    Alunno, Alessia
    Cipriani, Paola
    Di Benedetto, Paola
    Ruscitti, Piero
    Berardicurti, Onorina
    Bartoloni, Elena
    Bistoni, Onelia
    Caterbi, Sara
    Ciccia, Francesco
    Triolo, Giovanni
    Gerli, Roberto
    Giacomelli, Roberto
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2014, 44 (03) : 314 - 324
  • [19] LABIAL SALIVARY GLAND BIOPSY IN SJOGRENS DISEASE
    CHISHOLM, DM
    MASON, DK
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1968, 21 (05) : 656 - &
  • [20] Foxp3+ T-Regulatory Cells in Sjogren's Syndrome Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors
    Christodoulou, Maria I.
    Kapsogeorgou, Efstathia K.
    Moutsopoulos, Niki M.
    Moutsopoulos, Haralampos M.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2008, 173 (05) : 1389 - 1396
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