Salivary Gland Pathology in Sjogren's Syndrome

被引：30

作者：

Campos, Joana ^{[1
]}

Hillen, Maarten R. ^{[1
,2
]}

Barone, Francesca ^{[1
]}

机构：

[1] Univ Birmingham, Ctr Translat Inflammat Res, Inst Inflammat & Ageing, ARUK Ctr Pathogenesis Rheumatoid Arthrit,Queen El, Mindelsohn Way, Birmingham B15 2WB, W Midlands, England

[2] Univ Med Ctr Utrecht, Lab Translat Immunol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2016年 / 42卷 / 03期

基金：

英国医学研究理事会;

关键词：

Primary Sjogren's syndrome; Salivary glands; Histopathology; Autammune disease; HELPER T-CELLS; TERTIARY LYMPHOID STRUCTURES; MESSENGER-RNA EXPRESSION; ECTOPIC GERMINAL-CENTERS; B-CELLS; EPITHELIAL-CELLS; DENDRITIC CELLS; AUTOANTIBODY PRODUCTION; SYNDROME ASSOCIATION; AUTOIMMUNE-DISEASES;

D O I：

10.1016/j.rdc.2016.03.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary Sjogren's syndrome (pSS) can be considered a systemic autoimmune disease with a strong organ bias. The involvement of the exocrine glands is prevalent and drives the pathognothonic manifestations of dryness that define the sicca syndrome. The salivary glands also represent the hub of pSS pathology. Elements belonging to both innate and acquired immune responses have been described at this site that contribute to disease establishment and progression. The interaction between those elements and their relative contributions to the clinical manifestations and lymphoma progression largely remain to be addressed.

引用

页码：473 / +

页数：12

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