Synthesis of phenanthridine skeletal Amaryllidaceae alkaloids

被引：38
|
作者：
Fan-Chiang, Tai-Ting [1 ]
Wang, Hung-Kai [1 ]
Hsieh, Jen-Chieh [1 ]
机构：
[1] Tamkang Univ, Dept Chem, New Taipei 25137, Taiwan
来源：
TETRAHEDRON | 2016年 / 72卷 / 36期
关键词：
Amaryllidaceae alkaloid; DNA topoisomerase I; Suzuki coupling; Ullmann coupling; SNAr; COPPER-CATALYZED ANNULATION; VINYL GRIGNARD-REAGENTS; CONSTITUENTS; DERIVATIVES; LYCORINE; BULBS;
D O I：
10.1016/j.tet.2016.07.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Strategies for the synthesis of Amaryllidaceae alkaloids, including crinasiadine, trisphaeridine, bicolorine, N-methylcrinasiadine, 5,6-dihydrobicolorine, galanthindole, lycosinine A and lycosinine B were reported. Investigation of optionally synthetic routes to approach bicolorine, 5,6-dihydrobicolorine, trisphaeridine and N-methylcrinasiadine were demonstrated as well. In addition, three structurally related alkaloids galanthindole, lycosinine A and lycosinine B were concisely prepared by using Suzuki coupling reaction as the key step. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5640 / 5645
页数：6
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