Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage

被引：79

作者：

Chamilos, G. ^{[1
]}

Lewis, R. E. ^{[1
,2
]}

Lamaris, G. ^{[1
]}

Walsh, T. J. ^{[3
]}

Kontoyiannis, D. P. ^{[1
,2
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Unit 402, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA

[3] NCI, Pediat Oncol Branch, Immunocompromised Host Sect, Bethesda, MD 20892 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1128/AAC.01136-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O-2(-) release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-kappa B pathway-related genes.

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收藏

页码：722 / 724

页数：3

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