Effects of excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion in rats

被引：15

作者：

Reilly, S ^{[1
]}

Bornovalova, M ^{[1
]}

Dengler, C ^{[1
]}

Trifunovic, R ^{[1
]}

机构：

[1] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 62卷 / 02期

关键词：

gustatory thalamus; brain lesions; attentional processing; aversive conditioning; learning; rat;

D O I：

10.1016/j.brainresbull.2003.08.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of bilateral excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion (CTA) was examined in two experiments. In Experiment 1, rats with thalamic lesions showed normal latent inhibition by acquiring a CTA that was significantly weaker when the conditioned stimulus (CS) was familiar than when it was novel. In Experiment 2, the preconditioned element (sodium chloride) of a compound CS blocked the acquisition of a CTA to the novel element (sucrose) in normal rats. Irrespective of whether sodium chloride was preconditioned or not, rats with thalamic lesions showed little or no aversion to sucrose following compound conditioning. Overall, the results provide no support for the experimental hypothesis that thalamic lesions disrupt decremental changes in the attentional processing of gustatory stimuli. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：117 / 128

页数：12

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