Herpesviruses remodel host membranes for virus egress

被引：381

作者：

Johnson, David C. ^{[2
]}

Baines, Joel D. ^{[1
]}

机构：

[1] Cornell Univ, New York Coll Vet Med, Ithaca, NY 14853 USA

[2] Oregon Hlth & Sci Univ, Portland, OR 97219 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HERPES-SIMPLEX-VIRUS; TRANS-GOLGI NETWORK; TYPE-1 TEGUMENT PROTEIN; PRIMARY ENVELOPED VIRIONS; VARICELLA-ZOSTER-VIRUS; OUTER NUCLEAR-MEMBRANE; U(L)34 GENE-PRODUCTS; HUMAN CYTOMEGALOVIRUS; PSEUDORABIES VIRUS; INFECTED-CELLS;

D O I：

10.1038/nrmicro2559

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.

引用

页码：382 / 394

页数：13

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