Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

被引：19
作者：
Subramanian, Nithya [1 ,2 ]
Kanwar, Jagat R. [2 ]
Akilandeswari, Balachandran [2 ,4 ]
Kanwar, Rupinder K. [2 ]
Khetan, Vikas [3 ]
Krishnakumar, Subramanian [1 ,4 ]
机构：
[1] Vis Res Fdn, Kamalnayan Bajaj Inst Res Vis & Ophthalmol, Dept Nanobiotechnol, Madras, Tamil Nadu, India
[2] Deakin Univ, MMR Strateg Res Ctr, Sch Med, NLIMBR, Geelong, Vic 3217, Australia
[3] Med Res Fdn, Dept Ocular Oncol & Vitreoretina, Madras 600006, Tamil Nadu, India
[4] Vis Res Fdn, Kamalnayan Bajaj Inst Res Vis & Ophthalmol, L&T Ocular Pathol Dept, Madras, Tamil Nadu, India
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 32期
关键词：
MESSENGER-RNA; ADVANCED RETINOBLASTOMA; THERAPY; AS1411; PROLIFERATION; MIGRATION; CLEAVAGE; GROWTH; DEATH;
D O I：
10.1039/c5cc00939a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chimeric aptamer-DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.
引用
收藏
页码：6940 / 6943
页数：4
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