Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease

被引：104

作者：

Gomez-Nicola, Diego ^{[1
]}

Boche, Delphine ^{[2
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Fac Nat & Environm Sci, Ctr Biol Sci, Southampton SO16 6YD, Hants, England

[2] Univ Southampton, Southampton Gen Hosp, Fac Med, Clin Neurosci Clin & Expt Sci, Southampton SO16 6YD, Hants, England

来源：

ALZHEIMERS RESEARCH & THERAPY | 2015年 / 7卷

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; SYSTEMIC INFLAMMATION; ALTERNATIVE ACTIVATION; IDENTIFIES VARIANTS; COGNITIVE DECLINE; MOUSE MODELS; MICROGLIA; BRAIN; AD; EXPRESSION;

D O I：

10.1186/s13195-015-0126-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Since the genome-wide association studies in Alzheimer's disease have highlighted inflammation as a driver of the disease rather than a consequence of the ongoing neurodegeneration, numerous studies have been performed to identify specific immune profiles associated with healthy, ageing, or diseased brain. However, these studies have been performed mainly in in vitro or animal models, which recapitulate only some aspects of the pathophysiology of human Alzheimer's disease. In this review, we discuss the availability of human post-mortem tissue through brain banks, the limitations associated with its use, the technical tools available, and the neuroimmune aspects to explore in order to validate in the human brain the experimental observations arising from animal models.

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页数：8

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