Autologous stem cell transplantation for severe autoimmune diseases - A 10-year experience

被引：27

作者：

Gualandi, F.

Bruno, B.

van Lint, M. T.

Luchetti, S.

Uccelli, A.

Capello, E.

Mancardi, G. L.

Bacigalupo, A.

Marmont, A.

机构：

来源：

AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH | 2007年 / 1110卷

关键词：

Behcet's disease; BMT/SCT; multiple sclerosis; severe autoimmune diseases; SADs; stem cell transplant; systemic lupus erythematosus;

D O I：

10.1196/annals.1423.048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The first autologous hematopoictic stem cell transplantation in Europe for a patient with severe refractory systemic lupus erythematosus (SLE) was performed in Genoa in 1996. Since then, 32 patients with a wide spectrum of autoimmune diseases (ADs) received autologous transplants, 22 of them with multiple sclerosis (MS). There were no fatal adverse events. All patients had complete or very good partial remissions, but relapses were frequent, especially in SLE, though never as aggressive as pretransplant. The mechanism of action of this intervention remains not completely understood, as briefly discussed here.

引用

页码：455 / 464

页数：10

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