Effect of Low-, Moderate-, and High-Fat Meals on Raltegravir Pharmacokinetics

被引：41

作者：

Brainard, Diana M. ^{[1
]}

Friedman, Evan J. ^{[1
]}

Jin, Bo ^{[1
]}

Breidinger, Sheila A. ^{[1
]}

Tillan, Maria D. ^{[2
]}

Wenning, Larissa A. ^{[1
]}

Stone, Julie A. ^{[1
]}

Chodakewitz, Jeffrey A. ^{[1
]}

Wagner, John A. ^{[1
]}

Iwamoto, Marian ^{[1
]}

机构：

[1] Merck & Co Inc, Whitehouse Stn, NJ USA

[2] Covance Global Clin Pharmacol Inc, Gainesville, FL USA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2011年 / 51卷 / 03期

关键词：

Raltegravir; pharmacokinetics; food effect; INTEGRASE INHIBITOR RALTEGRAVIR; ACTIVE ANTIRETROVIRAL THERAPY; TREATMENT-NAIVE PATIENTS; HIV-1; INTEGRASE; HIV-1-INFECTED PATIENTS; COMBINATION THERAPY; INFECTION; ADHERENCE; MK-0518; AIDS;

D O I：

10.1177/0091270010367652

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：422 / 427

页数：6

共 26 条

[1] HIV-1 integrase: Structural organization, conformational changes, and catalysis [J].

Asante-Appiah, E ;

Skalka, AM .

ADVANCES IN VIRUS RESEARCH, VOL 52, 1999, 52 :351-369

[2] ASSOCIATION OF GASTRIC HYPOACIDITY WITH OPPORTUNISTIC ENTERIC INFECTIONS IN PATIENTS WITH AIDS [J].

BELITSOS, PC ;

GREENSON, JK ;

YARDLEY, JH ;

SISLER, JR ;

BARTLETT, JG .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (02) :277-284

[3]

*DHHS PAN ANT GUID, 2008, GUID US ANT AG HIV 1

[4] Determinants of adherence to highly active antiretroviral therapy among HIV-1-infected patients in C(o)over-capte d'Ivoire [J].

Diabate, Souleymane ;

Alary, Michel ;

Koffi, Constance Kanga .

AIDS, 2007, 21 (13) :1799-1803

[5] HIV integrase structure and function [J].

Esposito, D ;

Craigie, R .

ADVANCES IN VIRUS RESEARCH, VOL 52, 1999, 52 :319-333

[6]

*FDA CDER REG GUID, GUID IND FOOD EFF BI

[7]

GRINSZTEJN B, 2006, INT C ANT AG CHEM 46

[8]

GRINSZTEJN B, 2006, 13 C RETR OPP INF FE

[9] Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial [J].

Grinsztejn, Beatriz ;

Nguyen, Bach-Yen ;

Katlama, Christine ;

Gatell, Jose M. ;

Lazzarin, Adriano ;

Vittecoq, Daniel ;

Gonzalez, Charles J. ;

Chen, Joshua ;

Harvey, Charlotte M. ;

Isaacs, Robin D. .

LANCET, 2007, 369 (9569) :1261-1269

[10] Antiretroviral treatment of adult HIV infection - 2008 recommendations of the International AIDS Society USA panel [J].

Hammer, Scott M. ;

Eron, Joseph J., Jr. ;

Reiss, Peter ;

Schooley, Robert T. ;

Thompson, Melanie A. ;

Walmsley, Sharon ;

Cahn, Pedro ;

Fischl, Margaret A. ;

Gatell, Jose M. ;

Hirsch, Martin S. ;

Jacobsen, Donna M. ;

Montaner, Julio S. G. ;

Richman, Douglas D. ;

Yeni, Patrick G. ;

Volberding, Paul A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (05) :555-570

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