Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

被引：76

作者：

Yan, Li ^{[1
]}

Chen, Xianfeng ^{[2
]}

Wane, Zhigang ^{[8
]}

Zhang, Xiujuan ^{[6
,7
]}

Zhu, Xiaoyue ^{[3
,4
]}

Zhou, Mengjiao ^{[6
,7
]}

Chen, Wei ^{[3
,4
]}

Huang, Longbiao ^{[3
,4
]}

Roy, Vellaisamy A. L. ^{[3
,4
]}

Yu, Peter K. N. ^{[4
,5
]}

Zhu, Guangyu ^{[8
]}

Zhang, Wenjun ^{[3
,4
]}

机构：

[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610052, Sichuan, Peoples R China

[2] Univ Edinburgh, Inst Bioengn, Sch Engn, Mayfield Rd, Edinburgh EH9 3JL, Midlothian, Scotland

[3] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Dept Mat Sci & Engn, Hong Kong, Hong Kong, Peoples R China

[5] City Univ Hong Kong, Dept Phys, Hong Kong, Hong Kong, Peoples R China

[6] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[7] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[8] City Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 38期

关键词：

metal-organic frameworks; nanomaterials; ZIF-8; nanocomposites; drug delivery; METAL-ORGANIC FRAMEWORKS; MAGNETIC-RESONANCE; DELIVERY; NANOPARTICLES; THERAPY; FUNCTIONALIZATION; MOLECULES; CHEMISTRY; POROSITY;

D O I：

10.1021/acsami.7b10064

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8-poly(acrylic acid sodium salt) (ZIF-8-PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8-PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal-organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.

引用

页码：32990 / 33000

页数：11

共 2 条

[1] Chromium-Doped Zinc Gallogermanate@Zeolitic Imidazolate Framework-8: A Multifunctional Nanoplatform for Rechargeable In Vivo Persistent Luminescence Imaging and pH-Responsive Drug Release
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ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (02) : 1907 - 1916
[2] Reactive Oxygen Species Synergistic pH/H2O2-Responsive Poly(L-lactic acid)-block-poly(sodium 4-styrenesulfonate)/Citrate-Fe(III)@ZIF-8 Hybrid Nanocomposites for Controlled Drug Release
Lei, Zhentao
Ju, Yanshan
Lin, Yonghui
Bai, Xiaowen
Hu, Wei
Wang, Yaping
Luo, Haipeng
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ACS APPLIED BIO MATERIALS, 2019, 2 (08): : 3648 - 3658

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