Modeling brain deformations in Alzheimer disease by fluid registration of serial 3D MR images

被引：169

作者：

Freeborough, PA ^{[1
]}

Fox, NC ^{[1
]}

机构：

[1] UCL Natl Hosp Neurol & Neurosurg, Dementia Res Grp, London WC1N 3BG, England

来源：

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY | 1998年 / 22卷 / 05期

关键词：

image registration; Alzheimer disease; brain; diseases; magnetic resonance imaging; three-dimensional;

D O I：

10.1097/00004728-199809000-00031

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Serial 3D MR scan pairs (1 year intervals) from nine control subjects and nine Alzheimer disease (AD) patients were matched using an accurate fast fluid algorithm. Subtraction of matched scans indicated near complete cancellation of brain structure; mean cross-correlation coefficients were 0.946 (controls) and 0.933 (AD). In the AD group, regions of expansion and contraction in the deformation field were consistent with the known patterns of tissue loss and expansion of CSF spaces. Fluid registration may permit better localization of structural change.

引用

页码：838 / 843

页数：6

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