Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord

被引：76
作者：
Beiche, F
Klein, T
Nüsing, R
Neuhuber, W
Goppelt-Struebe, M [1 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Med 4, D-91054 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Dept Anat, D-91054 Erlangen, Germany
[3] Univ Marburg, Dept Pediat, D-35037 Marburg, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 89卷 / 1-2期
关键词：
prostaglandin G/H synthase; spinal cord; prostaglandin E-2 receptor EP3; immunocytochemistry;
D O I：
10.1016/S0165-5728(98)00061-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cyclooxygenase-2 (COX-2) is now considered to be the major constitutively expressed COX isozyme in the central nervous system. The present immunocytochemical study details localization of COX-2 immunoreactivity in rat spinal cord along with the expression of prostaglandin E-2 receptor subtype EP3. Prominent COX-2 staining was observed in the nuclear envelope of neurons throughout the spinal cord, especially in the superficial dorsal horn laminae and motoneurons of lamina IX, as well as in glial cells of the white matter. Expression of EP3 receptor was strictly confined to afferent terminal areas in the superficial dorsal horns. (C) 1998 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：26 / 34
页数：9
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