Icb-1 Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated With HER2 Expression

被引：2
作者：
Springwald, Anette [1 ]
Lattrich, Claus [1 ]
Skrzypczak, Maciej [2 ]
Goerse, Regina [1 ]
Ortmann, Olaf [1 ]
Treeck, Oliver [1 ]
机构：
[1] Univ Med Ctr Regensburg, Dept Obstet & Gynecol, Regensburg, Germany
[2] Med Univ Lublin, Dept Gynecol 2, Lublin, Poland
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 09期
关键词：
Icb-1; gene; C1orf38; Endometrial cancer; CANCER CELL-LINES; STEROID-RECEPTORS; POSITIVE SELECTION; KI-67; EXPRESSION; CARCINOMA; BREAST; DIFFERENTIATION; PROTEIN; OVARIAN; MARKER;
D O I：
10.3109/07357907.2010.483511
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human gene icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer.
引用
收藏
页码：904 / 909
页数：6
相关论文
共 50 条
  • [31] HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer
    Konecny, G. E.
    Santos, L.
    Winterhoff, B.
    Hatmal, M.
    Keeney, G. L.
    Mariani, A.
    Jones, M.
    Neuper, C.
    Thomas, B.
    Muderspach, L.
    Riehle, D.
    Wang, H-J
    Dowdy, S.
    Podratz, K. C.
    Press, M. F.
    BRITISH JOURNAL OF CANCER, 2009, 100 (01) : 89 - 95
  • [32] HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer
    G E Konecny
    L Santos
    B Winterhoff
    M Hatmal
    G L Keeney
    A Mariani
    M Jones
    C Neuper
    B Thomas
    L Muderspach
    D Riehle
    H-J Wang
    S Dowdy
    K C Podratz
    M F Press
    British Journal of Cancer, 2009, 100 : 89 - 95
  • [33] Effect of High Copy Number of HER2 Associated With Polysomy 17 on HER2 Protein Expression in Invasive Breast Carcinoma
    Shah, Sejal S.
    Wang, Yan
    Tull, Jamie
    Zhang, Shengle
    DIAGNOSTIC MOLECULAR PATHOLOGY, 2009, 18 (01) : 30 - 33
  • [34] The expression of HER2/neu in patients with lung cancer and its associated factors
    Lashkarizadeh, Mohammadreza
    Lashkarizadeh, Mahdiyeh
    Nikian, Meead
    Kouhestani Parizi, Maryam
    CLINICAL RESPIRATORY JOURNAL, 2023, 17 (02) : 90 - 95
  • [35] Immunohistochemical expression of CDX2, CK7, HER2 and HER4 in periampullary adenocarcinoma : implications for clinicopathology and patient outcomes
    Ugras, Nesrin
    Yerci, Omer
    Ozgun, Gonca
    Deligonul, Adem
    Dundar, Halit Ziya
    Sarkut, Pinar
    Uludag, Ozkan Kanat
    ACTA GASTRO-ENTEROLOGICA BELGICA, 2017, 80 (01) : 31 - 37
  • [36] In vivo molecular imaging of HER2 expression in a rat model of Barrett's esophagus adenocarcinoma
    Realdon, S.
    Dassie, E.
    Fassan, M.
    Dall'Olmo, L.
    Hatem, G.
    Buda, A.
    Arcidiacono, D.
    Diamantis, G.
    Zhang, H.
    Greene, M. I.
    Sturniolo, G. C.
    Rugge, M.
    Alberti, A.
    Battaglia, G.
    DISEASES OF THE ESOPHAGUS, 2015, 28 (04) : 394 - 403
  • [37] HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population
    Shan, Ling
    Ying, Jianming
    Lu, Ning
    DIAGNOSTIC PATHOLOGY, 2013, 8
  • [38] Protein Expression, Amplification, and Mutation of HER2 Gene in Canine Primary Pulmonary Adenocarcinomas: Preliminary Results
    Brunetti, Barbara
    de Biase, Dario
    Millanta, Francesca
    Muscatello, Luisa Vera
    Di Oto, Enrico
    Marchetti, Roberta
    Laddaga, Ester Lidia
    De Leo, Antonio
    Tallini, Giovanni
    Bacci, Barbara
    ANIMALS, 2024, 14 (18):
  • [39] Frequency of Human Epidermal Growth Factor Receptor 2 (Her2/Neu) Expression in Gastric Adenocarcinoma in Rehman Medical Institute Peshawar
    Khattak, Maria Tasneem
    Hassan, Masroor
    Nasib, Bushra
    Qamar, Muhammad Ashraf
    Javed, Sarah
    Ali, Nasir
    JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2019, 69 (06) : 788 - 793
  • [40] Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
    Rong, Lulu
    Zhao, Hongying
    Li, Yunlong
    Jin, Mulan
    Lu, Jun
    JOURNAL OF CLINICAL PATHOLOGY, 2024, 77 (04) : 233 - 238
12345