Icb-1 Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated With HER2 Expression

被引：2

作者：

Springwald, Anette ^{[1
]}

Lattrich, Claus ^{[1
]}

Skrzypczak, Maciej ^{[2
]}

Goerse, Regina ^{[1
]}

Ortmann, Olaf ^{[1
]}

Treeck, Oliver ^{[1
]}

机构：

[1] Univ Med Ctr Regensburg, Dept Obstet & Gynecol, Regensburg, Germany

[2] Med Univ Lublin, Dept Gynecol 2, Lublin, Poland

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 09期

关键词：

Icb-1; gene; C1orf38; Endometrial cancer; CANCER CELL-LINES; STEROID-RECEPTORS; POSITIVE SELECTION; KI-67; EXPRESSION; CARCINOMA; BREAST; DIFFERENTIATION; PROTEIN; OVARIAN; MARKER;

D O I：

10.3109/07357907.2010.483511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human gene icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer.

引用

页码：904 / 909

页数：6