Icb-1 Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated With HER2 Expression

被引：2
|
作者：
Springwald, Anette [1 ]
Lattrich, Claus [1 ]
Skrzypczak, Maciej [2 ]
Goerse, Regina [1 ]
Ortmann, Olaf [1 ]
Treeck, Oliver [1 ]
机构：
[1] Univ Med Ctr Regensburg, Dept Obstet & Gynecol, Regensburg, Germany
[2] Med Univ Lublin, Dept Gynecol 2, Lublin, Poland
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 09期
关键词：
Icb-1; gene; C1orf38; Endometrial cancer; CANCER CELL-LINES; STEROID-RECEPTORS; POSITIVE SELECTION; KI-67; EXPRESSION; CARCINOMA; BREAST; DIFFERENTIATION; PROTEIN; OVARIAN; MARKER;
D O I：
10.3109/07357907.2010.483511
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human gene icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer.
引用
收藏
页码：904 / 909
页数：6
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