Exploring the origins of grey matter damage in multiple sclerosis

被引：306

作者：

Calabrese, Massimiliano ^{[1
]}

Magliozzi, Roberta ^{[2
,3
]}

Ciccarelli, Olga ^{[4
,5
]}

Geurts, Jeroen J. G. ^{[6
]}

Reynolds, Richard ^{[2
]}

Martin, Roland ^{[7
]}

机构：

[1] Univ Hosp Verona, Dept Neurol & Movement Sci, Adv Neuroimaging Lab Neurol B, I-37134 Verona, Italy

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Div Brain Sci, London W12 0NN, England

[3] Ist Super Sanita, Department Cell Biol & Neurosci, I-00161 Rome, Italy

[4] UCL, Hosp NHS Fdn Trust NIHR UCL UCLH, Biomed Res Ctr, Natl Inst Hlth Res, London W1T 7DN, England

[5] UCL, Inst Neurol, Queen Sq Multiple Sclerosis Ctr, London WC1N 3BG, England

[6] Vrije Univ Amsterdam, Med Ctr, Dept Anat & Neurosci, Sect Clin Neurosci, NL-1081 BT Amsterdam, Netherlands

[7] Univ Zurich, Univ Zurich Hosp, Dept Neurol, Neuroimmunol & Multiple Sclerosis Res Sect, CH-8091 Zurich, Switzerland

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 03期

基金：

欧洲研究理事会; 英国医学研究理事会; 欧盟第七框架计划; 瑞士国家科学基金会;

关键词：

EPSTEIN-BARR-VIRUS; B-CELL FOLLICLES; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; VOXEL-BASED MORPHOMETRY; REGIONAL BRAIN ATROPHY; CD8(+) T-CELLS; WHITE-MATTER; CORTICAL-LESIONS; GRAY-MATTER; MENINGEAL INFLAMMATION;

D O I：

10.1038/nrn3900

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multiple sclerosis is characterized at the gross pathological level by the presence of widespread focal demyelinating lesions of the myelin-rich white matter. However, it is becoming clear that grey matter is not spared, even during the earliest phases of the disease. Furthermore, grey matter damage may have an important role both in physical and cognitive disability. Grey matter pathology involves both inflammatory and neurodegenerative mechanisms, but the relationship between the two is unclear. Histological, immunological and neuroimaging studies have provided new insight in this rapidly expanding field, and form the basis of the most recent hypotheses on the pathogenesis of grey matter damage.

引用

页码：147 / 158

页数：12

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