Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms

被引：13

作者：

Nourbakhsh, Fahimeh ^{[1
]}

Askari, Vahid Reza ^{[2
,3
]}

机构：

[1] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Fac Med, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Sch Persian & Complementary Med, Dept Pharmaceut Sci Persian Med, Azadi Sq, Mashhad 9177948564, Razavi Khorasan, Iran

来源：

BIOFACTORS | 2021年 / 47卷 / 06期

关键词：

bradykinins; cancer; noscapine; receptors; microtubule targeting drugs; therapeutics; TOLL-LIKE RECEPTORS; INHIBITS TUMOR-GROWTH; OVARIAN-CANCER CELLS; NF-KAPPA-B; IN-VITRO; ANTICANCER ACTIVITY; MEDIATED APOPTOSIS; RATIONAL DESIGN; KINASE; DERIVATIVES;

D O I：

10.1002/biof.1781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noscapine has been mentioned as one of the effective drugs with potential therapeutic applications. With few side effects and amazing capabilities, noscapine can be considered different from other opioids-like structure compounds. Since 1930, extensive studies have been conducted in the field of pharmacological treatments from against malaria to control cough and cancer treatment. Furthermore, recent studies have shown that noscapine and some analogues, like 9-bromonoscapine, amino noscapine, and 9-nitronoscapine, can be used to treat polycystic ovaries syndrome, stroke, and other diseases. Given the numerous results presented in this field and the role of different receptors in the therapeutic effects of noscapine, we aimed to review the properties, therapeutic effects, and the role of receptors in the treatment of noscapine.

引用

页码：975 / 991

页数：17

共 117 条

[1] Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy [J].

Abdalla, Mohamed O. ;

Karna, Prasanthi ;

Sajja, Hari Krishna ;

Mao, Hui ;

Yates, Clayton ;

Turner, Timothy ;

Aneja, Ritu .

JOURNAL OF CONTROLLED RELEASE, 2011, 149 (03) :314-322

[2] Determination of Noscapine's Localization and Interaction with the Tubulin-α/β Heterodimer [J].

Alisaraie, Laleh ;

Tuszynski, Jack A. .

CHEMICAL BIOLOGY & DRUG DESIGN, 2011, 78 (04) :535-546

[3] ILLICIT HEROIN MANUFACTURING BY-PRODUCTS - CAPILLARY GAS-CHROMATOGRAPHIC DETERMINATION AND STRUCTURAL ELUCIDATION OF NARCOTINE-RELATED AND NORLAUDANOSINE-RELATED COMPOUNDS [J].

ALLEN, AC ;

COOPER, DA ;

MOORE, JM ;

GLOGER, M ;

NEUMANN, H .

ANALYTICAL CHEMISTRY, 1984, 56 (14) :2940-2947

[4] Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro [J].

Altinoz, Meric A. ;

Bilir, Ayhan ;

Del Maestro, Rolando F. ;

Tuna, Sevilcan ;

Ozcan, Emin ;

Gedikoglu, Gunduz .

SURGICAL NEUROLOGY, 2006, 65 (05) :478-485

[5] Noscapine, a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma [J].

Altinoz, Meric A. ;

Topcu, Gulacti ;

Hacimuftuoglu, Ahmet ;

Ozpinar, Alp ;

Ozpinar, Aysel ;

Hacker, Emily ;

Elmaci, Ilhan .

NEUROCHEMICAL RESEARCH, 2019, 44 (08) :1796-1806

[6] Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine [J].

Andey, Terrick ;

Patel, Apurva ;

Marepally, Srujan ;

Chougule, Mahavir ;

Spencer, Shawn D. ;

Rishi, Arun K. ;

Singh, Mandip .

PLOS ONE, 2016, 11 (01)

[7] Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent [J].

Aneja, Ritu ;

Dhiman, Neerupma ;

Idnani, Jyoti ;

Awasthi, Anshumali ;

Arora, Sudershan K. ;

Chandra, Ramesh ;

Joshi, Harish C. .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 60 (06) :831-839

[8] p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells [J].

Aneja, Ritu ;

Ghaleb, Amr M. ;

Zhou, Jun ;

Yang, Vincent W. ;

Joshi, Harish C. .

CANCER RESEARCH, 2007, 67 (08) :3862-3870

[9] Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and t-cell lymphoma [J].

Aneja, Ritu ;

Vangapandu, Surya N. ;

Lopus, Manu ;

Chandra, Ramesh ;

Panda, Dulal ;

Joshi, Harish C. .

MOLECULAR PHARMACOLOGY, 2006, 69 (06) :1801-1809

[10] A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells [J].

Aneja, Ritu ;

Miyagi, Tohru ;

Karna, Prasanthi ;

Ezell, Tucker ;

Shukla, Deep ;

Gupta, Meenakshi Vij ;

Yates, Clayton ;

Chinni, Sreenivasa R. ;

Zhau, Haiyen ;

Chung, Leland W. K. ;

Joshi, Harish C. .

EUROPEAN JOURNAL OF CANCER, 2010, 46 (09) :1668-1678

← 1 2 3 4 5 6 7 8 9 10 →